ICD-10-CM 2027 diagnosis code
D57.4Sickle-cell thalassemia
D57.4 is a header code, so it can't be reported by itself. Choose one of the 6 more specific codes beneath it.
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About D57.4
D57.4 is the ICD-10-CM diagnosis code for sickle-cell thalassemia. It belongs to category D57 (sickle-cell disorders), block D55-D59 (hemolytic anemias) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is a header code, so it can't be reported by itself; one of its 6 subcodes must be used instead.
Within D57 (sickle-cell disorders), D57.4 is specifically for sickle-cell thalassemia. Related codes cover Hb-SS disease with crisis (D57.0), sickle-cell disease without crisis (D57.1), Sickle-cell/Hb-C disease (D57.2), sickle-cell trait (D57.3) and other sickle-cell disorders (D57.8).
To report this condition, pick the subcode that matches the documentation: D57.40 (without crisis), D57.41 (unspecified, with crisis), D57.42 (beta zero without crisis), D57.43 (beta zero with crisis), D57.44 (beta plus without crisis) and D57.45 (beta plus with crisis).
Use an additional code for any associated fever (R50.81).
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Specific codes under D57.4
- D57.40Sickle-cell thalassemia without crisisBillable
- D57.41Sickle-cell thalassemia, unspecified, with crisis
- D57.411Sickle-cell thalassemia, unspecified, with acute chest syndromeBillable
- D57.412Sickle-cell thalassemia, unspecified, with splenic sequestrationBillable
- D57.413Sickle-cell thalassemia, unspecified, with cerebral vascular involvementBillable
- D57.414Sickle-cell thalassemia, unspecified, with dactylitisBillable
- D57.418Sickle-cell thalassemia, unspecified, with crisis with other specified complicationBillable
- D57.419Sickle-cell thalassemia, unspecified, with crisisBillable
- D57.42Sickle-cell thalassemia beta zero without crisisBillable
- D57.43Sickle-cell thalassemia beta zero with crisis
- D57.431Sickle-cell thalassemia beta zero with acute chest syndromeBillable
- D57.432Sickle-cell thalassemia beta zero with splenic sequestrationBillable
- D57.433Sickle-cell thalassemia beta zero with cerebral vascular involvementBillable
- D57.434Sickle-cell thalassemia beta zero with dactylitisBillable
- D57.438Sickle-cell thalassemia beta zero with crisis with other specified complicationBillable
- D57.439Sickle-cell thalassemia beta zero with crisis, unspecifiedBillable
- D57.44Sickle-cell thalassemia beta plus without crisisBillable
- D57.45Sickle-cell thalassemia beta plus with crisis
- D57.451Sickle-cell thalassemia beta plus with acute chest syndromeBillable
- D57.452Sickle-cell thalassemia beta plus with splenic sequestrationBillable
- D57.453Sickle-cell thalassemia beta plus with cerebral vascular involvementBillable
- D57.454Sickle-cell thalassemia beta plus with dactylitisBillable
- D57.458Sickle-cell thalassemia beta plus with crisis with other specified complicationBillable
- D57.459Sickle-cell thalassemia beta plus with crisis, unspecifiedBillable
Coding notes
- Sickle-cell beta thalassemia
- Thalassemia Hb-S disease
Notes that apply from higher levels
Instructions written at a parent level also apply to D57.4.
› From D57 Sickle-cell disorders
Broader instructions also apply from Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism.
Codes whose notes reference D57.4
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about D57.4
Is D57.4 billable?
- No. D57.4 is a header code. Report one of its more specific subcodes instead.