ICD-10-CM 2027
ICD-10 code for DPD
From the official ICD-10-CM alphabetic index entry “DPD (dihydropyrimidine dehydrogenase deficiency)”. Page updated September 29, 2026.
About coding DPD
The ICD-10-CM code for DPD is E88.89 (Other specified metabolic disorders).
Within E88.8, choose E88.89 (Other specified metabolic disorders) only when documentation doesn't support a more specific option: metabolic syndrome and other insulin resistance (E88.81) and obesity due to disruption of MC4R pathway (E88.82).
Don't report E88.89 together with the conditions in its Excludes1 note: adult pulmonary Langerhans cell histiocytosis (J84.82).
Use an additional code for: codes for associated conditions.
Don't confuse with (Excludes1 for E88.89)
- adult pulmonary Langerhans cell histiocytosis (J84.82)
Common questions about DPD ICD-10 codes
What is the ICD-10 code for DPD?
- E88.89 — Other specified metabolic disorders.
Is E88.89 billable?
- Yes. E88.89 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E88.89 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E88.89 as a principal diagnosis.
Is E88.89 a CC or MCC?
- No. E88.89 is neither a CC nor an MCC under MS-DRG v44.0.