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ICD-10-CM 2027 diagnosis code

E88.82Obesity due to disruption of MC4R pathway

✓ Billable / specific

E88.82 is a valid, billable ICD-10-CM code for obesity due to disruption of mc4r pathway. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Code last changed in FY2025 (effective October 1, 2024). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E88.82

E88.82 is the ICD-10-CM diagnosis code for obesity due to disruption of MC4R pathway. It belongs to category E88 (other and unspecified metabolic disorders), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E88.8 (other specified metabolic disorders), E88.82 is specifically for obesity due to disruption of MC4R pathway. Related codes cover metabolic syndrome and other insulin resistance (E88.81) and other specified metabolic disorders (E88.89).

Use an additional code, if applicable, to identify associated manifestations, such as polyphagia (R63.2). Use an additional code to identify body mass index (BMI), if known (Z68.-). Use an additional code for: codes for associated conditions.

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It was added in FY2025, effective October 1, 2024.

Coding notes

Use additional codeAdd a secondary code to fully describe the condition
  • code, if applicable, to identify associated manifestations, such as polyphagia (R63.2)
  • code to identify body mass index (BMI), if known (Z68.-)

Notes that apply from higher levels

Instructions written at a parent level also apply to E88.82.

› From E88 Other and unspecified metabolic disorders
Excludes1
  • histiocytosis X (chronic) (C96.6)
Use additional code
  • codes for associated conditions

Broader instructions also apply from E70-E88 Metabolic disorders and Chapter 4: Endocrine, nutritional and metabolic diseases.

Alphabetic index entries

8 entries

Terms in the official ICD-10-CM index that lead to E88.82.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

MDC 10 · Endocrine, Nutritional and Metabolic Diseases and Disorders

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2025 (effective 10/1/2024): Added
  • No changes since FY2025.

Common questions about E88.82

Is E88.82 billable?

Yes. E88.82 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can E88.82 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict E88.82 as a principal diagnosis.

Is E88.82 a CC or MCC?

No. E88.82 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does E88.82 group to?

E88.82 is used in the MS-DRG v44.0 logic for MS-DRG 642 (Inborn and Other Disorders of Metabolism). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.