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ICD-10-CM 2027 diagnosis code

E88.8Other specified metabolic disorders

Not billable — use a more specific code

E88.8 is a header code, so it can't be reported by itself. Choose one of the 3 more specific codes beneath it.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E88.8

E88.8 is the ICD-10-CM diagnosis code for other specified metabolic disorders. It belongs to category E88 (other and unspecified metabolic disorders), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is a header code, so it can't be reported by itself; one of its 3 subcodes must be used instead.

Within E88, choose E88.8 (Other specified metabolic disorders) only when documentation doesn't support a more specific option: disorders of plasma-protein metabolism, not elsewhere classified (E88.0), lipodystrophy, not elsewhere classified (E88.1), Lipomatosis, not elsewhere classified (E88.2), tumor lysis syndrome (E88.3), mitochondrial metabolism disorders (E88.4), metabolic disorder, unspecified (E88.9) and wasting disease (syndrome) due to underlying condition (E88.A).

To report this condition, pick the subcode that matches the documentation: E88.81 (resistance), E88.82 (pathway) and E88.89 (disorders).

Use an additional code for: codes for associated conditions.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Specific codes under E88.8

Notes that apply from higher levels

Instructions written at a parent level also apply to E88.8.

› From E88 Other and unspecified metabolic disorders
Excludes1
  • histiocytosis X (chronic) (C96.6)
Use additional code
  • codes for associated conditions

Broader instructions also apply from E70-E88 Metabolic disorders and Chapter 4: Endocrine, nutritional and metabolic diseases.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about E88.8

Is E88.8 billable?

No. E88.8 is a header code. Report one of its more specific subcodes instead.