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ICD-10-CM 2027 diagnosis code

E88.81Metabolic syndrome and other insulin resistance

Not billable — use a more specific code

E88.81 is a header code, so it can't be reported by itself. Choose one of the 4 more specific codes beneath it.

Code last changed in FY2024 (effective October 1, 2023). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E88.81

E88.81 is the ICD-10-CM diagnosis code for metabolic syndrome and other insulin resistance. It belongs to category E88 (other and unspecified metabolic disorders), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is a header code, so it can't be reported by itself; one of its 4 subcodes must be used instead.

Within E88.8, choose E88.81 (Metabolic syndrome and other insulin resistance) only when documentation doesn't support a more specific option: obesity due to disruption of MC4R pathway (E88.82) and other specified metabolic disorders (E88.89).

To report this condition, pick the subcode that matches the documentation: E88.810 (syndrome), E88.811 (A), E88.818 (resistance) and E88.819 (unspecified).

Use an additional code codes for associated manifestations, such as: obesity (E66.-) and codes for associated conditions.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015, and changed in FY2024 (title revised).

Before ICD-10, this condition was coded in ICD-9-CM as 277.7 (Dysmetabolic syndrome X).

Specific codes under E88.81

Coding notes

Use additional codeAdd a secondary code to fully describe the condition
  • codes for associated manifestations, such as:
  • obesity (E66.-)

Notes that apply from higher levels

Instructions written at a parent level also apply to E88.81.

› From E88 Other and unspecified metabolic disorders
Excludes1
  • histiocytosis X (chronic) (C96.6)
Use additional code
  • codes for associated conditions

Broader instructions also apply from E70-E88 Metabolic disorders and Chapter 4: Endocrine, nutritional and metabolic diseases.

Codes whose notes reference E88.81

ICD-9-CM equivalent

Converter →
  • 277.7Dysmetabolic syndrome Xexact

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • FY2024 (effective 10/1/2023): Title revised — was “Metabolic syndrome”

Common questions about E88.81

Is E88.81 billable?

No. E88.81 is a header code. Report one of its more specific subcodes instead.

What is the ICD-9 code for E88.81?

The CMS General Equivalence Mappings map E88.81 to ICD-9-CM 277.7.