ICD-10-CM 2027
ICD-10 code for Epinephrine hypersecretion
From the official ICD-10-CM alphabetic index entry “Hypersecretion › epinephrine”. Page updated September 29, 2026.
About coding Epinephrine hypersecretion
The ICD-10-CM code for Epinephrine hypersecretion is E27.5 (Adrenomedullary hyperfunction).
Within E27 (other disorders of adrenal gland), E27.5 is specifically for Adrenomedullary hyperfunction. Related codes cover other adrenocortical overactivity (E27.0), primary adrenocortical insufficiency (E27.1), Addisonian crisis (E27.2), drug-induced adrenocortical insufficiency (E27.3), other and unspecified adrenocortical insufficiency (E27.4), other specified disorders of adrenal gland (E27.8) and disorder of adrenal gland, unspecified (E27.9).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about Epinephrine hypersecretion ICD-10 codes
What is the ICD-10 code for Epinephrine hypersecretion?
- E27.5 — Adrenomedullary hyperfunction.
Is E27.5 billable?
- Yes. E27.5 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E27.5 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E27.5 as a principal diagnosis.
Is E27.5 a CC or MCC?
- E27.5 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.