ICD-10 code for erythrocyte fragmentation syndrome

The ICD-10-CM code for erythrocyte fragmentation syndrome is D59.4 (Other nonautoimmune hemolytic anemias).

Within D59, choose D59.4 (Other nonautoimmune hemolytic anemias) only when documentation doesn't support a more specific option: drug-induced autoimmune hemolytic anemia (D59.0), other autoimmune hemolytic anemias (D59.1), drug-induced nonautoimmune hemolytic anemia (D59.2), hemolytic-uremic syndrome (D59.3), paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] (D59.5), hemoglobinuria due to hemolysis from other external causes (D59.6), other acquired hemolytic anemias (D59.8) and unspecified (D59.9).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 791 (Prematurity with Major Problems, relative weight 4.1075), DRG 793 (Full Term Neonate with Major Problems, relative weight 4.2195), DRG 808 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC, relative weight 2.1705), DRG 809 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC, relative weight 1.2262) and DRG 810 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC, relative weight 1.075), in MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period) and MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.