ICD-10-CM 2027 diagnosis code
D59.2Drug-induced nonautoimmune hemolytic anemia
D59.2 is a valid, billable ICD-10-CM code for drug-induced nonautoimmune hemolytic anemia. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About D59.2
D59.2 is the ICD-10-CM diagnosis code for drug-induced nonautoimmune hemolytic anemia. It belongs to category D59 (acquired hemolytic anemia), block D55-D59 (hemolytic anemias) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within D59 (acquired hemolytic anemia), D59.2 is specifically for drug-induced nonautoimmune hemolytic anemia. Related codes cover drug-induced autoimmune hemolytic anemia (D59.0), other autoimmune hemolytic anemias (D59.1), hemolytic-uremic syndrome (D59.3), other nonautoimmune hemolytic anemias (D59.4), paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] (D59.5), hemoglobinuria due to hemolysis from other external causes (D59.6), other acquired hemolytic anemias (D59.8) and unspecified (D59.9).
Use an additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 791 (Prematurity with Major Problems, relative weight 4.1075), DRG 793 (Full Term Neonate with Major Problems, relative weight 4.2195), DRG 808 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC, relative weight 2.1705), DRG 809 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC, relative weight 1.2262) and DRG 810 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC, relative weight 1.075), in MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period) and MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Before ICD-10, this condition was coded in ICD-9-CM as 283.19 (other non-autoimmune hemolytic anemias).
Coding notes
Notes that apply from higher levels
Instructions written at a parent level also apply to D59.2.
Broader instructions also apply from Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism.
Alphabetic index entries
7 entriesTerms in the official ICD-10-CM index that lead to D59.2.
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › enzyme › drug-induced (hemolytic)
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › enzyme-deficiency, drug-induced
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › due to › drugs (nonautoimmune)
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › due to › enzyme disorder › drug-induced
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › nonautoimmune › drug-induced
- Disease, diseased › nonautoimmune hemolytic › drug-induced
- Nonautoimmune hemolytic anemia › drug-induced
Codes whose notes reference D59.2
- D55Excludes1
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 15 · Newborns and Other Neonates with Conditions Originating in the Perinatal Period
MDC 15 · Newborns and Other Neonates with Conditions Originating in the Perinatal Period
MDC 16 · Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders
- 808Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCCRW 2.1705
- 809Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CCRW 1.2262
- 810Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCCRW 1.075
ICD-9-CM equivalent
Converter →- 283.19Other non-autoimmune hemolytic anemiasapproximate
From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about D59.2
Is D59.2 billable?
- Yes. D59.2 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D59.2 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D59.2 as a principal diagnosis.
Is D59.2 a CC or MCC?
- D59.2 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.
What DRG does D59.2 group to?
- D59.2 is used in the MS-DRG v44.0 logic for MS-DRG 791 (Prematurity with Major Problems), MS-DRG 793 (Full Term Neonate with Major Problems), MS-DRG 808 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC), MS-DRG 809 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC) and MS-DRG 810 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.
What is the ICD-9 code for D59.2?
- The CMS General Equivalence Mappings map D59.2 to ICD-9-CM 283.19.