ICD-10-CM 2027
ICD-10 code for Gammaglobulin in blood deficiency
From the official ICD-10-CM alphabetic index entry “Deficiency, deficient › gammaglobulin in blood”. Page updated September 29, 2026.
About coding Gammaglobulin in blood deficiency
The ICD-10-CM code for Gammaglobulin in blood deficiency is D80.1 (Nonfamilial hypogammaglobulinemia). The official index lists 1 more specific code, so check the documentation for details such as type, cause, site or severity before settling on D80.1.
Within D80 (immunodeficiency with predominantly antibody defects), D80.1 is specifically for nonfamilial hypogammaglobulinemia. Related codes cover hereditary hypogammaglobulinemia (D80.0), selective deficiency of immunoglobulin A [IgA] (D80.2), selective deficiency of immunoglobulin G [IgG] subclasses (D80.3), selective deficiency of immunoglobulin M [IgM] (D80.4), immunodeficiency with increased immunoglobulin M [IgM] (D80.5), antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia (D80.6), transient hypogammaglobulinemia of infancy (D80.7), other immunodeficiencies with predominantly antibody defects (D80.8) and 1 more.
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 814 (Reticuloendothelial and Immunity Disorders with MCC, relative weight 2.0729), DRG 815 (Reticuloendothelial and Immunity Disorders with CC, relative weight 1.0444) and DRG 816 (Reticuloendothelial and Immunity Disorders without CC/MCC, relative weight 0.7381), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific Gammaglobulin in blood deficiency codes (official index)
- hereditary D80.0 — Hereditary hypogammaglobulinemia
Common questions about Gammaglobulin in blood deficiency ICD-10 codes
What is the ICD-10 code for Gammaglobulin in blood deficiency?
- D80.1 — Nonfamilial hypogammaglobulinemia. More specific codes apply when the documentation supports them: D80.0.
What is the ICD-10 code for hereditary gammaglobulin in blood deficiency?
- D80.0 — Hereditary hypogammaglobulinemia.
Is D80.1 billable?
- Yes. D80.1 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D80.1 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D80.1 as a principal diagnosis.
Is D80.1 a CC or MCC?
- D80.1 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.