ICD-10-CM 2027
ICD-10 code for Hemoglobinemia
From the official ICD-10-CM alphabetic index entry “Hemoglobinemia”. Page updated September 29, 2026.
About coding Hemoglobinemia
The ICD-10-CM code for Hemoglobinemia is D59.9 (Acquired hemolytic anemia, unspecified). The official index lists 3 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on D59.9.
Within D59, choose D59.9 (unspecified) only when documentation doesn't support a more specific option: drug-induced autoimmune hemolytic anemia (D59.0), other autoimmune hemolytic anemias (D59.1), drug-induced nonautoimmune hemolytic anemia (D59.2), hemolytic-uremic syndrome (D59.3), other nonautoimmune hemolytic anemias (D59.4), paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] (D59.5), hemoglobinuria due to hemolysis from other external causes (D59.6) and other acquired hemolytic anemias (D59.8).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 791 (Prematurity with Major Problems, relative weight 4.1075), DRG 793 (Full Term Neonate with Major Problems, relative weight 4.2195), DRG 808 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC, relative weight 2.1705), DRG 809 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC, relative weight 1.2262) and DRG 810 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC, relative weight 1.075), in MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period) and MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific Hemoglobinemia codes (official index)
Common questions about Hemoglobinemia ICD-10 codes
What is the ICD-10 code for Hemoglobinemia?
- D59.9 — Acquired hemolytic anemia, unspecified. More specific codes apply when the documentation supports them: T80.89, D59.6, D59.5.
What is the ICD-10 code for paroxysmal hemoglobinemia?
- D59.6 — Hemoglobinuria due to hemolysis from other external causes.
Is D59.9 billable?
- Yes. D59.9 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D59.9 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D59.9 as a principal diagnosis.
Is D59.9 a CC or MCC?
- D59.9 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.