ICD-10-CM 2027
ICD-10 code for Microdrepanocytosis
From the official ICD-10-CM alphabetic index entry “Microdrepanocytosis”. Page updated September 29, 2026.
About coding Microdrepanocytosis
The ICD-10-CM code for Microdrepanocytosis is D57.40 (Sickle-cell thalassemia without crisis). The official index lists 6 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on D57.40.
Within D57.4, choose D57.40 (without crisis) only when documentation doesn't support a more specific option: unspecified, with crisis (D57.41), beta zero without crisis (D57.42), beta zero with crisis (D57.43), beta plus without crisis (D57.44) and beta plus with crisis (D57.45).
Use an additional code for any associated fever (R50.81).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
More specific Microdrepanocytosis codes (official index)
- with
- acute chest syndrome D57.411 — Sickle-cell thalassemia, unspecified, with acute chest syndrome
- cerebral vascular involvement D57.413 — Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
- crisis (painful) D57.419 — Sickle-cell thalassemia, unspecified, with crisis
- with specified complication NEC D57.418 — Sickle-cell thalassemia, unspecified, with crisis with other specified complication
- pain (vaso-occlusive) D57.419 — Sickle-cell thalassemia, unspecified, with crisis
- splenic sequestration D57.412 — Sickle-cell thalassemia, unspecified, with splenic sequestration
Common questions about Microdrepanocytosis ICD-10 codes
What is the ICD-10 code for Microdrepanocytosis?
- D57.40 — Sickle-cell thalassemia without crisis. More specific codes apply when the documentation supports them: D57.411, D57.413, D57.419, D57.418 and others below.
Is D57.40 billable?
- Yes. D57.40 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D57.40 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D57.40 as a principal diagnosis.
Is D57.40 a CC or MCC?
- No. D57.40 is neither a CC nor an MCC under MS-DRG v44.0.