D57.45Sickle-cell thalassemia beta plus with crisis

D57.45 is the ICD-10-CM diagnosis code for sickle-cell thalassemia beta plus with crisis. It belongs to category D57 (sickle-cell disorders), block D55-D59 (hemolytic anemias) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is a header code, so it can't be reported by itself; one of its 6 subcodes must be used instead.

Within D57.4 (sickle-cell thalassemia), D57.45 is specifically for sickle-cell thalassemia beta plus with crisis. Related codes cover without crisis (D57.40), unspecified, with crisis (D57.41), beta zero without crisis (D57.42), beta zero with crisis (D57.43) and beta plus without crisis (D57.44).

To report this condition, pick the subcode that matches the documentation: D57.451 (syndrome), D57.452 (sequestration), D57.453 (involvement), D57.454 (dactylitis), D57.458 (with other specified complication) and D57.459 (unspecified).

Use an additional code for any associated fever (R50.81).

It was added in FY2021, effective October 1, 2020.