ICD-10-CM 2027
ICD-10 code for nocturnal paroxysmal hemoglobinuria
From the official ICD-10-CM alphabetic index entry “Hemoglobinuria › nocturnal (paroxysmal)”. Page updated September 29, 2026.
About coding nocturnal paroxysmal hemoglobinuria
The ICD-10-CM code for nocturnal paroxysmal hemoglobinuria is D59.5 (Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]).
Within D59 (acquired hemolytic anemia), D59.5 is specifically for paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]. Related codes cover drug-induced autoimmune hemolytic anemia (D59.0), other autoimmune hemolytic anemias (D59.1), drug-induced nonautoimmune hemolytic anemia (D59.2), hemolytic-uremic syndrome (D59.3), other nonautoimmune hemolytic anemias (D59.4), hemoglobinuria due to hemolysis from other external causes (D59.6), other acquired hemolytic anemias (D59.8) and unspecified (D59.9).
Don't report D59.5 together with the conditions in its Excludes1 note: hemoglobinuria NOS (R82.3).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
Don't confuse with (Excludes1 for D59.5)
- hemoglobinuria NOS (R82.3)
Common questions about nocturnal paroxysmal hemoglobinuria ICD-10 codes
What is the ICD-10 code for nocturnal paroxysmal hemoglobinuria?
- D59.5 — Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli].
Is D59.5 billable?
- Yes. D59.5 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D59.5 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D59.5 as a principal diagnosis.
Is D59.5 a CC or MCC?
- No. D59.5 is neither a CC nor an MCC under MS-DRG v44.0.