ICD-10-CM 2027
ICD-10 code for peroxidase defect
From the official ICD-10-CM alphabetic index entry “Defect, defective › peroxidase”. Page updated September 29, 2026.
About coding peroxidase defect
The ICD-10-CM code for peroxidase defect is E80.3 (Defects of catalase and peroxidase).
Within E80 (disorders of porphyrin and bilirubin metabolism), E80.3 is specifically for defects of catalase and peroxidase. Related codes cover hereditary erythropoietic porphyria (E80.0), porphyria cutanea tarda (E80.1), other and unspecified porphyria (E80.2), Gilbert syndrome (E80.4), Crigler-Najjar syndrome (E80.5), other disorders of bilirubin metabolism (E80.6) and disorder of bilirubin metabolism, unspecified (E80.7).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about peroxidase defect ICD-10 codes
What is the ICD-10 code for peroxidase defect?
- E80.3 — Defects of catalase and peroxidase.
Is E80.3 billable?
- Yes. E80.3 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E80.3 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E80.3 as a principal diagnosis.
Is E80.3 a CC or MCC?
- E80.3 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.