E80.4Gilbert syndrome

E80.4 is the ICD-10-CM diagnosis code for Gilbert syndrome. It belongs to category E80 (disorders of porphyrin and bilirubin metabolism), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E80 (disorders of porphyrin and bilirubin metabolism), E80.4 is specifically for Gilbert syndrome. Related codes cover hereditary erythropoietic porphyria (E80.0), porphyria cutanea tarda (E80.1), other and unspecified porphyria (E80.2), defects of catalase and peroxidase (E80.3), Crigler-Najjar syndrome (E80.5), other disorders of bilirubin metabolism (E80.6) and disorder of bilirubin metabolism, unspecified (E80.7).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 441 (Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis with MCC, relative weight 1.8219), DRG 442 (Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis with CC, relative weight 0.9602) and DRG 443 (Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis without CC/MCC, relative weight 0.6885), in MDC 07 (Diseases and Disorders of the Hepatobiliary System and Pancreas), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 277.4 (disorders of bilirubin excretion).