ICD-10-CM 2027
ICD-10 code for polyglandular dysfunction
From the official ICD-10-CM alphabetic index entry “Dysfunction › polyglandular”. Page updated September 29, 2026.
About coding polyglandular dysfunction
The ICD-10-CM code for polyglandular dysfunction is E31.9 (Polyglandular dysfunction, unspecified). The official index lists 1 more specific code, so check the documentation for details such as type, cause, site or severity before settling on E31.9.
Within E31, choose E31.9 (unspecified) only when documentation doesn't support a more specific option: autoimmune polyglandular failure (E31.0), polyglandular hyperfunction (E31.1), multiple endocrine neoplasia [MEN] syndromes (E31.2) and other polyglandular dysfunction (E31.8).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific polyglandular dysfunction codes (official index)
- specified NEC E31.8 — Other polyglandular dysfunction
Common questions about polyglandular dysfunction ICD-10 codes
What is the ICD-10 code for polyglandular dysfunction?
- E31.9 — Polyglandular dysfunction, unspecified. More specific codes apply when the documentation supports them: E31.8.
Is E31.9 billable?
- Yes. E31.9 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E31.9 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E31.9 as a principal diagnosis.
Is E31.9 a CC or MCC?
- No. E31.9 is neither a CC nor an MCC under MS-DRG v44.0.