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ICD-10-CM 2027 diagnosis code

E31.0Autoimmune polyglandular failure

✓ Billable / specific

E31.0 is a valid, billable ICD-10-CM code for autoimmune polyglandular failure. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Looking up by condition? See ICD-10 code for Schmidt's syndrome.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E31.0

E31.0 is the ICD-10-CM diagnosis code for autoimmune polyglandular failure. It belongs to category E31 (polyglandular dysfunction), block E20-E35 (disorders of other endocrine glands) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E31 (polyglandular dysfunction), E31.0 is specifically for autoimmune polyglandular failure. Related codes cover polyglandular hyperfunction (E31.1), multiple endocrine neoplasia [MEN] syndromes (E31.2), other polyglandular dysfunction (E31.8) and unspecified (E31.9).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 258.1 (other combinations of endocrine dysfunction).

Coding notes

Applicable toConditions and synonyms classified to this code
  • Schmidt's syndrome

Notes that apply from higher levels

Instructions written at a parent level also apply to E31.0.

› From E31 Polyglandular dysfunction
Excludes1
  • ataxia telangiectasia [Louis-Bar] (G11.3)
  • dystrophia myotonica [Steinert] (G71.11)
  • pseudohypoparathyroidism (E20.1)

Broader instructions also apply from E20-E35 Disorders of other endocrine glands and Chapter 4: Endocrine, nutritional and metabolic diseases.

Alphabetic index entries

10 entries

Terms in the official ICD-10-CM index that lead to E31.0.

Codes whose notes reference E31.0

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

ICD-9-CM equivalent

Converter →
  • 258.1Other combinations of endocrine dysfunctionapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about E31.0

Is E31.0 billable?

Yes. E31.0 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can E31.0 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict E31.0 as a principal diagnosis.

Is E31.0 a CC or MCC?

No. E31.0 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does E31.0 group to?

E31.0 is used in the MS-DRG v44.0 logic for MS-DRG 643 (Endocrine Disorders with MCC), MS-DRG 644 (Endocrine Disorders with CC) and MS-DRG 645 (Endocrine Disorders without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for E31.0?

The CMS General Equivalence Mappings map E31.0 to ICD-9-CM 258.1.