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ICD-10-CM 2027

ICD-10 code for syphilis

A53.9

Syphilis, unspecified

✓ Billable / specific

From the official ICD-10-CM alphabetic index entry “Syphilis, syphilitic (acquired)”. Page updated September 29, 2026.

About coding syphilis

The ICD-10-CM code for syphilis is A53.9 (Syphilis, unspecified). The official index lists 283+ more specific codes, so check the documentation for details such as type, cause, site or severity before settling on A53.9.

Within A53, choose A53.9 (Syphilis, unspecified) only when documentation doesn't support a more specific option: latent syphilis, unspecified as early or late (A53.0).

Don't report A53.9 together with the conditions in its Excludes1 note: syphilis NOS under two years of age (A50.2).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

More specific syphilis codes (official index)

  • abdomen (late) A52.79 — Other symptomatic late syphilis
  • acoustic nerve A52.15 — Late syphilitic neuropathy
  • adenopathy (secondary) A51.49 — Other secondary syphilitic conditions
  • adrenal (gland) (with cortical hypofunction) A52.79 — Other symptomatic late syphilis
  • age under 2 years NOS
  • acquired A51.9 — Early syphilis, unspecified
  • alopecia (secondary) A51.32 — Syphilitic alopecia
  • anemia (late) A52.79 — Other symptomatic late syphilis
  • aneurysm (aorta) (ruptured) A52.01 — Syphilitic aneurysm of aorta
  • central nervous system A52.05 — Other cerebrovascular syphilis
  • congenital A50.54 — Late congenital cardiovascular syphilis
  • anus (late) A52.74 — Syphilis of liver and other viscera
  • primary A51.1 — Primary anal syphilis
  • secondary A51.39 — Other secondary syphilis of skin
  • aorta (arch) (abdominal) (thoracic) A52.02 — Syphilitic aortitis
  • aneurysm A52.01 — Syphilitic aneurysm of aorta
  • aortic (insufficiency) (regurgitation) (stenosis) A52.03 — Syphilitic endocarditis
  • aneurysm A52.01 — Syphilitic aneurysm of aorta
  • arachnoid (adhesive) (cerebral) (spinal) A52.13 — Late syphilitic meningitis
  • asymptomatic
  • ataxia (locomotor) A52.11 — Tabes dorsalis
  • atrophoderma maculatum A51.39 — Other secondary syphilis of skin
  • auricular fibrillation A52.06 — Other syphilitic heart involvement
  • bladder (late) A52.76 — Other genitourinary symptomatic late syphilis
  • bone A52.77 — Syphilis of bone and joint
  • secondary A51.46 — Secondary syphilitic osteopathy
  • brain A52.17 — General paresis
  • breast (late) A52.79 — Other symptomatic late syphilis
  • bronchus (late) A52.72 — Syphilis of lung and bronchus
  • bubo (primary) A51.0 — Primary genital syphilis
  • bulbar palsy A52.19 — Other symptomatic neurosyphilis
  • bursa (late) A52.78 — Syphilis of other musculoskeletal tissue
  • cardiac decompensation A52.06 — Other syphilitic heart involvement
  • cardiovascular A52.00 — Cardiovascular syphilis, unspecified
  • central nervous system (late) (recurrent) (relapse) (tertiary) A52.3 — Neurosyphilis, unspecified
  • with
  • ataxia A52.11 — Tabes dorsalis
  • general paralysis A52.17 — General paresis
  • juvenile A50.45 — Juvenile general paresis
  • paresis (general) A52.17 — General paresis
  • juvenile A50.45 — Juvenile general paresis
  • tabes (dorsalis) A52.11 — Tabes dorsalis
  • juvenile A50.45 — Juvenile general paresis
  • taboparesis A52.17 — General paresis
  • juvenile A50.45 — Juvenile general paresis
  • aneurysm A52.05 — Other cerebrovascular syphilis
  • congenital A50.40 — Late congenital neurosyphilis, unspecified
  • juvenile A50.40 — Late congenital neurosyphilis, unspecified
  • remission in (sustained) A52.3 — Neurosyphilis, unspecified
  • serology doubtful, negative, or positive A52.3 — Neurosyphilis, unspecified
  • specified nature or site NEC A52.19 — Other symptomatic neurosyphilis
  • vascular A52.05 — Other cerebrovascular syphilis
  • cerebral A52.17 — General paresis
  • meningovascular A52.13 — Late syphilitic meningitis
  • nerves (multiple palsies) A52.15 — Late syphilitic neuropathy
  • sclerosis A52.17 — General paresis
  • thrombosis A52.05 — Other cerebrovascular syphilis
  • cerebrospinal (tabetic type) A52.12 — Other cerebrospinal syphilis
  • cerebrovascular A52.05 — Other cerebrovascular syphilis
  • cervix (late) A52.76 — Other genitourinary symptomatic late syphilis
  • chancre (multiple) A51.0 — Primary genital syphilis
  • extragenital A51.2 — Primary syphilis of other sites
  • Rollet's A51.0 — Primary genital syphilis
  • Charcot's joint A52.16 — Charcot's arthropathy (tabetic)
  • chorioretinitis A51.43 — Secondary syphilitic oculopathy
  • congenital A50.01 — Early congenital syphilitic oculopathy
  • late A52.71 — Late syphilitic oculopathy
  • prenatal A50.01 — Early congenital syphilitic oculopathy
  • choroiditis
  • choroidoretinitis
  • ciliary body (secondary) A51.43 — Secondary syphilitic oculopathy
  • late A52.71 — Late syphilitic oculopathy
  • colon (late) A52.74 — Syphilis of liver and other viscera
  • combined spinal sclerosis A52.11 — Tabes dorsalis
  • condyloma (latum) A51.31 — Condyloma latum
  • congenital A50.9 — Congenital syphilis, unspecified
  • with
  • paresis (general) A50.45 — Juvenile general paresis
  • tabes (dorsalis) A50.45 — Juvenile general paresis
  • taboparesis A50.45 — Juvenile general paresis
  • chorioretinitis, choroiditis A50.01 — Early congenital syphilitic oculopathy
  • early, or less than 2 years after birth NEC A50.2 — Early congenital syphilis, unspecified
  • with manifestations
  • latent (without manifestations) A50.1 — Early congenital syphilis, latent
  • negative spinal fluid test A50.1 — Early congenital syphilis, latent
  • serology positive A50.1 — Early congenital syphilis, latent
  • symptomatic A50.09 — Other early congenital syphilis, symptomatic
  • cutaneous A50.06 — Early cutaneous congenital syphilis
  • mucocutaneous A50.07 — Early mucocutaneous congenital syphilis
  • oculopathy A50.01 — Early congenital syphilitic oculopathy
  • osteochondropathy A50.02 — Early congenital syphilitic osteochondropathy
  • pharyngitis A50.03 — Early congenital syphilitic pharyngitis
  • pneumonia A50.04 — Early congenital syphilitic pneumonia
  • rhinitis A50.05 — Early congenital syphilitic rhinitis
  • visceral A50.08 — Early visceral congenital syphilis
  • interstitial keratitis A50.31 — Late congenital syphilitic interstitial keratitis
  • juvenile neurosyphilis A50.45 — Juvenile general paresis
  • late, or 2 years or more after birth NEC A50.7 — Late congenital syphilis, unspecified
  • chorioretinitis, choroiditis A50.32 — Late congenital syphilitic chorioretinitis
  • interstitial keratitis A50.31 — Late congenital syphilitic interstitial keratitis
  • juvenile neurosyphilis A50.45 — Juvenile general paresis
  • latent (without manifestations) A50.6 — Late congenital syphilis, latent
  • negative spinal fluid test A50.6 — Late congenital syphilis, latent
  • serology positive A50.6 — Late congenital syphilis, latent
  • symptomatic or with manifestations NEC A50.59 — Other late congenital syphilis, symptomatic
  • arthropathy A50.55 — Late congenital syphilitic arthropathy
  • cardiovascular A50.54 — Late congenital cardiovascular syphilis
  • Clutton's joints A50.51 — Clutton's joints
  • Hutchinson's teeth A50.52 — Hutchinson's teeth
  • Hutchinson's triad A50.53 — Hutchinson's triad
  • osteochondropathy A50.56 — Late congenital syphilitic osteochondropathy
  • saddle nose A50.57 — Syphilitic saddle nose
  • conjugal A53.9 — Syphilis, unspecified
  • tabes A52.11 — Tabes dorsalis
  • conjunctiva (late) A52.71 — Late syphilitic oculopathy
  • contact Z20.2 — Contact with and (suspected) exposure to infections with a predominantly sexual mode of transmission
  • cord bladder A52.19 — Other symptomatic neurosyphilis
  • cornea, late A52.71 — Late syphilitic oculopathy
  • coronary (artery) (sclerosis) A52.06 — Other syphilitic heart involvement
  • coryza, congenital A50.05 — Early congenital syphilitic rhinitis
  • cranial nerve A52.15 — Late syphilitic neuropathy
  • multiple palsies A52.15 — Late syphilitic neuropathy
  • cutaneous
  • dacryocystitis (late) A52.71 — Late syphilitic oculopathy
  • degeneration, spinal cord A52.12 — Other cerebrospinal syphilis
  • dementia paralytica A52.17 — General paresis
  • juvenilis A50.45 — Juvenile general paresis
  • destruction of bone A52.77 — Syphilis of bone and joint
  • dilatation, aorta A52.01 — Syphilitic aneurysm of aorta
  • due to blood transfusion A53.9 — Syphilis, unspecified
  • dura mater A52.13 — Late syphilitic meningitis
  • ear A52.79 — Other symptomatic late syphilis
  • inner A52.79 — Other symptomatic late syphilis
  • nerve (eighth) A52.15 — Late syphilitic neuropathy
  • neurorecurrence A52.15 — Late syphilitic neuropathy
  • early A51.9 — Early syphilis, unspecified
  • cardiovascular A52.00 — Cardiovascular syphilis, unspecified
  • central nervous system A52.3 — Neurosyphilis, unspecified
  • latent (without manifestations) (less than 2 years after infection) A51.5 — Early syphilis, latent
  • negative spinal fluid test A51.5 — Early syphilis, latent
  • serological relapse after treatment A51.5 — Early syphilis, latent
  • serology positive A51.5 — Early syphilis, latent
  • relapse (treated, untreated) A51.9 — Early syphilis, unspecified
  • skin A51.39 — Other secondary syphilis of skin
  • symptomatic A51.9 — Early syphilis, unspecified
  • extragenital chancre A51.2 — Primary syphilis of other sites
  • primary, except extragenital chancre A51.0 — Primary genital syphilis
  • secondary A51.39 — Other secondary syphilis of skin
  • relapse (treated, untreated) A51.49 — Other secondary syphilitic conditions
  • ulcer A51.39 — Other secondary syphilis of skin
  • eighth nerve (neuritis) A52.15 — Late syphilitic neuropathy
  • endemic A65 — Nonvenereal syphilis
  • endocarditis A52.03 — Syphilitic endocarditis
  • aortic A52.03 — Syphilitic endocarditis
  • pulmonary A52.03 — Syphilitic endocarditis
  • epididymis (late) A52.76 — Other genitourinary symptomatic late syphilis
  • epiglottis (late) A52.73 — Symptomatic late syphilis of other respiratory organs
  • epiphysitis (congenital) (early) A50.02 — Early congenital syphilitic osteochondropathy
  • episcleritis (late) A52.71 — Late syphilitic oculopathy
  • esophagus A52.79 — Other symptomatic late syphilis
  • eustachian tube A52.73 — Symptomatic late syphilis of other respiratory organs
  • exposure to Z20.2 — Contact with and (suspected) exposure to infections with a predominantly sexual mode of transmission
  • eye A52.71 — Late syphilitic oculopathy
  • eyelid (late) (with gumma) A52.71 — Late syphilitic oculopathy
  • fallopian tube (late) A52.76 — Other genitourinary symptomatic late syphilis
  • fracture A52.77 — Syphilis of bone and joint
  • gallbladder (late) A52.74 — Syphilis of liver and other viscera
  • gastric (polyposis) (late) A52.74 — Syphilis of liver and other viscera
  • general A53.9 — Syphilis, unspecified
  • paralysis A52.17 — General paresis
  • juvenile A50.45 — Juvenile general paresis
  • genital (primary) A51.0 — Primary genital syphilis
  • glaucoma A52.71 — Late syphilitic oculopathy
  • gumma NEC A52.79 — Other symptomatic late syphilis
  • cardiovascular system A52.00 — Cardiovascular syphilis, unspecified
  • central nervous system A52.3 — Neurosyphilis, unspecified
  • congenital A50.59 — Other late congenital syphilis, symptomatic
  • heart (block) (decompensation) (disease) (failure) A52.06 — Other syphilitic heart involvement
  • valve NEC A52.03 — Syphilitic endocarditis
  • hemianesthesia A52.19 — Other symptomatic neurosyphilis
  • hemianopsia A52.71 — Late syphilitic oculopathy
  • hemiparesis A52.17 — General paresis
  • hemiplegia A52.17 — General paresis
  • hepatic artery A52.09 — Other cardiovascular syphilis
  • hepatis A52.74 — Syphilis of liver and other viscera
  • hepatomegaly, congenital A50.08 — Early visceral congenital syphilis
  • hereditaria tarda
  • hereditary
  • Hutchinson's teeth A50.52 — Hutchinson's teeth
  • hyalitis A52.71 — Late syphilitic oculopathy
  • inactive
  • infantum
  • inherited
  • internal ear A52.79 — Other symptomatic late syphilis
  • intestine (late) A52.74 — Syphilis of liver and other viscera
  • iris, iritis (secondary) A51.43 — Secondary syphilitic oculopathy
  • late A52.71 — Late syphilitic oculopathy
  • joint (late) A52.77 — Syphilis of bone and joint
  • keratitis (congenital) (interstitial) (late) A50.31 — Late congenital syphilitic interstitial keratitis
  • kidney (late) A52.75 — Syphilis of kidney and ureter
  • lacrimal passages (late) A52.71 — Late syphilitic oculopathy
  • larynx (late) A52.73 — Symptomatic late syphilis of other respiratory organs
  • late A52.9 — Late syphilis, unspecified
  • cardiovascular A52.00 — Cardiovascular syphilis, unspecified
  • central nervous system A52.3 — Neurosyphilis, unspecified
  • kidney A52.75 — Syphilis of kidney and ureter
  • latent or 2 years or more after infection (without manifestations) A52.8 — Late syphilis, latent
  • negative spinal fluid test A52.8 — Late syphilis, latent
  • serology positive A52.8 — Late syphilis, latent
  • paresis A52.17 — General paresis
  • specified site NEC A52.79 — Other symptomatic late syphilis
  • symptomatic or with manifestations A52.79 — Other symptomatic late syphilis
  • tabes A52.11 — Tabes dorsalis
  • latent A53.0 — Latent syphilis, unspecified as early or late
  • with signs or symptoms - code by site and stage under Syphilis
  • central nervous system A52.2 — Asymptomatic neurosyphilis
  • date of infection unspecified A53.0 — Latent syphilis, unspecified as early or late
  • early, or less than 2 years after infection A51.5 — Early syphilis, latent
  • follow-up of latent syphilis A53.0 — Latent syphilis, unspecified as early or late
  • date of infection unspecified A53.0 — Latent syphilis, unspecified as early or late
  • late, or 2 years or more after infection A52.8 — Late syphilis, latent
  • late, or 2 years or more after infection A52.8 — Late syphilis, latent
  • positive serology (only finding) A53.0 — Latent syphilis, unspecified as early or late
  • date of infection unspecified A53.0 — Latent syphilis, unspecified as early or late
  • early, or less than 2 years after infection A51.5 — Early syphilis, latent
  • late, or 2 years or more after infection A52.8 — Late syphilis, latent
  • lens (late) A52.71 — Late syphilitic oculopathy
  • leukoderma A51.39 — Other secondary syphilis of skin
  • late A52.79 — Other symptomatic late syphilis
  • lienitis A52.79 — Other symptomatic late syphilis
  • lip A51.39 — Other secondary syphilis of skin
  • chancre (primary) A51.2 — Primary syphilis of other sites
  • late A52.79 — Other symptomatic late syphilis
  • Lissauer's paralysis A52.17 — General paresis
  • liver A52.74 — Syphilis of liver and other viscera
  • locomotor ataxia A52.11 — Tabes dorsalis
  • lung A52.72 — Syphilis of lung and bronchus
  • lymph gland (early) (secondary) A51.49 — Other secondary syphilitic conditions
  • late A52.79 — Other symptomatic late syphilis
  • lymphadenitis (secondary) A51.49 — Other secondary syphilitic conditions
  • macular atrophy of skin A51.39 — Other secondary syphilis of skin
  • striated A52.79 — Other symptomatic late syphilis
  • mediastinum (late) A52.73 — Symptomatic late syphilis of other respiratory organs
  • meninges (adhesive) (brain) (spinal cord) A52.13 — Late syphilitic meningitis
  • meningitis A52.13 — Late syphilitic meningitis
  • acute (secondary) A51.41 — Secondary syphilitic meningitis
  • congenital A50.41 — Late congenital syphilitic meningitis
  • meningoencephalitis A52.14 — Late syphilitic encephalitis
  • meningovascular A52.13 — Late syphilitic meningitis
  • congenital A50.41 — Late congenital syphilitic meningitis
  • mesarteritis A52.09 — Other cardiovascular syphilis
  • brain A52.04 — Syphilitic cerebral arteritis
  • middle ear A52.77 — Syphilis of bone and joint
  • mitral stenosis A52.03 — Syphilitic endocarditis
  • monoplegia A52.17 — General paresis
  • mouth (secondary) A51.39 — Other secondary syphilis of skin
  • late A52.79 — Other symptomatic late syphilis
  • mucocutaneous (secondary) A51.39 — Other secondary syphilis of skin
  • late A52.79 — Other symptomatic late syphilis
  • mucous
  • membrane (secondary) A51.39 — Other secondary syphilis of skin
  • late A52.79 — Other symptomatic late syphilis
  • patches A51.39 — Other secondary syphilis of skin
  • congenital A50.07 — Early mucocutaneous congenital syphilis
  • mulberry molars A50.52 — Hutchinson's teeth
  • muscle A52.78 — Syphilis of other musculoskeletal tissue
  • myocardium A52.06 — Other syphilitic heart involvement
  • nasal sinus (late) A52.73 — Symptomatic late syphilis of other respiratory organs
  • neonatorum
  • nephrotic syndrome (secondary) A51.44 — Secondary syphilitic nephritis
  • nerve palsy (any cranial nerve) A52.15 — Late syphilitic neuropathy
  • multiple A52.15 — Late syphilitic neuropathy
  • nervous system, central A52.3 — Neurosyphilis, unspecified
  • neuritis A52.15 — Late syphilitic neuropathy
  • acoustic A52.15 — Late syphilitic neuropathy
  • neurorecidive of retina A52.19 — Other symptomatic neurosyphilis
  • neuroretinitis A52.19 — Other symptomatic neurosyphilis
  • newborn
  • nodular superficial (late) A52.79 — Other symptomatic late syphilis
  • nonvenereal A65 — Nonvenereal syphilis
  • nose (late) A52.73 — Symptomatic late syphilis of other respiratory organs
  • saddle back deformity A50.57 — Syphilitic saddle nose
  • occlusive arterial disease A52.09 — Other cardiovascular syphilis
  • oculopathy A52.71 — Late syphilitic oculopathy
  • ophthalmic (late) A52.71 — Late syphilitic oculopathy
  • optic nerve (atrophy) (neuritis) (papilla) A52.15 — Late syphilitic neuropathy
  • orbit (late) A52.71 — Late syphilitic oculopathy
  • organic A53.9 — Syphilis, unspecified
  • osseous (late) A52.77 — Syphilis of bone and joint
  • osteochondritis (congenital) (early) A50.02 — Early congenital syphilitic osteochondropathy
  • osteoporosis A52.77 — Syphilis of bone and joint
  • ovary (late) A52.76 — Other genitourinary symptomatic late syphilis
  • oviduct (late) A52.76 — Other genitourinary symptomatic late syphilis
  • palate (late) A52.79 — Other symptomatic late syphilis
  • pancreas (late) A52.74 — Syphilis of liver and other viscera
  • paralysis A52.17 — General paresis
  • general A52.17 — General paresis
  • juvenile A50.45 — Juvenile general paresis
  • paresis (general) A52.17 — General paresis
  • juvenile A50.45 — Juvenile general paresis

See all 441 entries in the alphabetic index

Don't confuse with (Excludes1 for A53.9)

  • syphilis NOS under two years of age (A50.2)

Common questions about syphilis ICD-10 codes

What is the ICD-10 code for syphilis?

A53.9 — Syphilis, unspecified. More specific codes apply when the documentation supports them: A52.79, A52.15, A51.49, A52.79 and others below.

What is the ICD-10 code for abdomen syphilis?

A52.79 — Other symptomatic late syphilis.

What is the ICD-10 code for acoustic nerve syphilis?

A52.15 — Late syphilitic neuropathy.

What is the ICD-10 code for adenopathy syphilis?

A51.49 — Other secondary syphilitic conditions.

What is the ICD-10 code for adrenal syphilis?

A52.79 — Other symptomatic late syphilis.

What is the ICD-10 code for alopecia syphilis?

A51.32 — Syphilitic alopecia.

What is the ICD-10 code for anemia syphilis?

A52.79 — Other symptomatic late syphilis.

Is A53.9 billable?

Yes. A53.9 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can A53.9 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict A53.9 as a principal diagnosis.

Is A53.9 a CC or MCC?

No. A53.9 is neither a CC nor an MCC under MS-DRG v44.0.