ICD-10-CM 2027 diagnosis code
C22.1Intrahepatic bile duct carcinoma
C22.1 is a valid, billable ICD-10-CM code for intrahepatic bile duct carcinoma. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.
Looking up by condition? See ICD-10 code for Bile duct type adenocarcinoma.
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About C22.1
C22.1 is the ICD-10-CM diagnosis code for intrahepatic bile duct carcinoma. It belongs to category C22 (malignant neoplasm of liver and intrahepatic bile ducts), block C15-C26 (malignant neoplasms of digestive organs) and chapter 2 (neoplasms). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within C22 (malignant neoplasm of liver and intrahepatic bile ducts), C22.1 is specifically for intrahepatic bile duct carcinoma. Related codes cover liver cell carcinoma (C22.0), Hepatoblastoma (C22.2), Angiosarcoma of liver (C22.3), other sarcomas of liver (C22.4), other specified carcinomas of liver (C22.7), malignant neoplasm of liver, primary, unspecified as to type (C22.8) and malignant neoplasm of liver, not specified as primary or secondary (C22.9).
Don't report C22.1 together with the conditions in its Excludes1 note: malignant neoplasm of hepatic duct (C24.0).
Use an additional code to identify: alcohol abuse and dependence (F10.-), hepatitis B (B16.-, B18.0-B18.1) and hepatitis C (B17.1-, B18.2).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 435 (Malignancy of Hepatobiliary System or Pancreas with MCC, relative weight 1.843), DRG 436 (Malignancy of Hepatobiliary System or Pancreas with CC, relative weight 1.1224) and DRG 437 (Malignancy of Hepatobiliary System or Pancreas without CC/MCC, relative weight 0.8081), in MDC 07 (Diseases and Disorders of the Hepatobiliary System and Pancreas), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Before ICD-10, this condition was coded in ICD-9-CM as 155.1 (malignant neoplasm of intrahepatic bile ducts).
Coding notes
- Cholangiocarcinoma
- malignant neoplasm of hepatic duct (C24.0)
Notes that apply from higher levels
Instructions written at a parent level also apply to C22.1.
Broader instructions also apply from C15-C26 Malignant neoplasms of digestive organs and Chapter 2: Neoplasms.
Alphabetic index entries
9 entriesTerms in the official ICD-10-CM index that lead to C22.1.
- Adenocarcinoma › bile duct type
- Adenocarcinoma › bile duct type › liver
- Adenocarcinoma › bile duct type › unspecified site
- Cancer › bile duct type liver
- Carcinoma (malignant) › bile duct › liver
- Carcinoma (malignant) › bile duct › unspecified site
- Cholangiocarcinoma › liver
- Cholangiocarcinoma › unspecified site
- Cystadenocarcinoma › bile duct
Table of Drugs & Neoplasms entries
- Neoplasm, neoplastic › bile or biliary (tract) › canaliculi (biliferi) (intrahepatic) — Malignant Primary
- Neoplasm, neoplastic › bile or biliary (tract) › canals, interlobular — Malignant Primary
- Neoplasm, neoplastic › bile or biliary (tract) › duct or passage (common) (cystic) (extrahepatic) › interlobular — Malignant Primary
- Neoplasm, neoplastic › bile or biliary (tract) › duct or passage (common) (cystic) (extrahepatic) › intrahepatic — Malignant Primary
- Neoplasm, neoplastic › canaliculi, biliary (biliferi) (intrahepatic) — Malignant Primary
- Neoplasm, neoplastic › cholangiole — Malignant Primary
- Neoplasm, neoplastic › gall duct (extrahepatic) › intrahepatic — Malignant Primary
- Neoplasm, neoplastic › intrahepatic (bile) duct — Malignant Primary
Codes whose notes reference C22.1
- C24Excludes1
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 07 · Diseases and Disorders of the Hepatobiliary System and Pancreas
ICD-9-CM equivalent
Converter →- 155.1Malignant neoplasm of intrahepatic bile ductsexact
From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about C22.1
Is C22.1 billable?
- Yes. C22.1 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can C22.1 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict C22.1 as a principal diagnosis.
Is C22.1 a CC or MCC?
- C22.1 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.
What DRG does C22.1 group to?
- C22.1 is used in the MS-DRG v44.0 logic for MS-DRG 435 (Malignancy of Hepatobiliary System or Pancreas with MCC), MS-DRG 436 (Malignancy of Hepatobiliary System or Pancreas with CC) and MS-DRG 437 (Malignancy of Hepatobiliary System or Pancreas without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.
What is the ICD-9 code for C22.1?
- The CMS General Equivalence Mappings map C22.1 to ICD-9-CM 155.1.