ICD-10-CM 2027 diagnosis code
C88Malignant immunoproliferative diseases and certain other B-cell lymphomas
C88 is a header code, so it can't be reported by itself. Choose one of the 6 more specific codes beneath it.Short description: Malig immunoproliferative dis and certain oth B-cell lymph
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About C88
C88 is the ICD-10-CM diagnosis code for malignant immunoproliferative diseases and certain other B-cell lymphomas. It belongs to block C81-C96 (malignant neoplasms of lymphoid, hematopoietic and related tissue) and chapter 2 (neoplasms). It is a header code, so it can't be reported by itself; one of its 6 subcodes must be used instead.
To report this condition, pick the subcode that matches the documentation: C88.0 (macroglobulinemia), C88.2 (disease), C88.3 (disease), C88.4 ([MALT-lymphoma]), C88.8 (diseases) and C88.9 (unspecified).
Don't report C88 together with the conditions in its Excludes1 note: B-cell lymphoma, unspecified (C85.1-) and personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues (Z85.79).
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Specific codes under C88
- C88.0Waldenstrom macroglobulinemia
- C88.2Heavy chain disease
- C88.3Immunoproliferative small intestinal disease
- C88.4Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
- C88.8Other malignant immunoproliferative diseases
- C88.9Malignant immunoproliferative disease, unspecified
Coding notes
Notes that apply from higher levels
Instructions written at a parent level also apply to C88.
Broader instructions also apply from C81-C96 Malignant neoplasms of lymphoid, hematopoietic and related tissue and Chapter 2: Neoplasms.
Codes whose notes reference C88
- C77Excludes1
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about C88
Is C88 billable?
- No. C88 is a header code. Report one of its more specific subcodes instead.