C88.3Immunoproliferative small intestinal disease

C88.3 is the ICD-10-CM diagnosis code for immunoproliferative small intestinal disease. It belongs to category C88 (malignant immunoproliferative diseases and certain other B-cell lymphomas), block C81-C96 (malignant neoplasms of lymphoid, hematopoietic and related tissue) and chapter 2 (neoplasms). It is a header code, so it can't be reported by itself; one of its 2 subcodes must be used instead.

Within C88 (malignant immunoproliferative diseases and certain other B-cell lymphomas), C88.3 is specifically for immunoproliferative small intestinal disease. Related codes cover Waldenstrom macroglobulinemia (C88.0), heavy chain disease (C88.2), extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] (C88.4), other malignant immunoproliferative diseases (C88.8) and malignant immunoproliferative disease, unspecified (C88.9).

To report this condition, pick the subcode that matches the documentation: C88.30 (not having achieved remission) and C88.31 (in remission).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015, and changed in FY2025 (expanded into subcodes).

Before ICD-10, this condition was coded in ICD-9-CM as 203.80 (other immunoproliferative neoplasms, without mention of having achieved remission).