C88.9Malignant immunoproliferative disease, unspecified

C88.9 is the ICD-10-CM diagnosis code for malignant immunoproliferative disease, unspecified. It belongs to category C88 (malignant immunoproliferative diseases and certain other B-cell lymphomas), block C81-C96 (malignant neoplasms of lymphoid, hematopoietic and related tissue) and chapter 2 (neoplasms). It is a header code, so it can't be reported by itself; one of its 2 subcodes must be used instead.

Within C88, choose C88.9 (Malignant immunoproliferative disease, unspecified) only when documentation doesn't support a more specific option: Waldenstrom macroglobulinemia (C88.0), heavy chain disease (C88.2), immunoproliferative small intestinal disease (C88.3), extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] (C88.4) and other malignant immunoproliferative diseases (C88.8).

To report this condition, pick the subcode that matches the documentation: C88.90 (not having achieved remission) and C88.91 (in remission).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015, and changed in FY2025 (expanded into subcodes).

Before ICD-10, this condition was coded in ICD-9-CM as 203.80 (other immunoproliferative neoplasms, without mention of having achieved remission).