C88.4Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]

C88.4 is the ICD-10-CM diagnosis code for extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]. It belongs to category C88 (malignant immunoproliferative diseases and certain other B-cell lymphomas), block C81-C96 (malignant neoplasms of lymphoid, hematopoietic and related tissue) and chapter 2 (neoplasms). It is a header code, so it can't be reported by itself; one of its 2 subcodes must be used instead.

Within C88 (malignant immunoproliferative diseases and certain other B-cell lymphomas), C88.4 is specifically for extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]. Related codes cover Waldenstrom macroglobulinemia (C88.0), heavy chain disease (C88.2), immunoproliferative small intestinal disease (C88.3), other malignant immunoproliferative diseases (C88.8) and malignant immunoproliferative disease, unspecified (C88.9).

To report this condition, pick the subcode that matches the documentation: C88.40 (not having achieved remission) and C88.41 (in remission).

Don't report C88.4 together with the conditions in its Excludes1 note: high malignant (diffuse large B-cell) lymphoma (C83.3-).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015, and changed in FY2025 (expanded into subcodes).

Before ICD-10, this condition was coded in ICD-9-CM as 200.30 (marginal zone lymphoma, unspecified site, extranodal and solid organ sites).