Skip to content
Dx

ICD-10-CM 2027 diagnosis code

D57.21Sickle-cell/Hb-C disease with crisis

Not billable — use a more specific code

D57.21 is a header code, so it can't be reported by itself. Choose one of the 6 more specific codes beneath it.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About D57.21

D57.21 is the ICD-10-CM diagnosis code for Sickle-cell/Hb-C disease with crisis. It belongs to category D57 (sickle-cell disorders), block D55-D59 (hemolytic anemias) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is a header code, so it can't be reported by itself; one of its 6 subcodes must be used instead.

Within D57.2 (Sickle-cell/Hb-C disease), D57.21 is specifically for Sickle-cell/Hb-C disease with crisis. Related codes cover without crisis (D57.20).

To report this condition, pick the subcode that matches the documentation: D57.211 (syndrome), D57.212 (sequestration), D57.213 (involvement), D57.214 (dactylitis), D57.218 (with other specified complication) and D57.219 (unspecified).

Use an additional code for any associated fever (R50.81).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Specific codes under D57.21

Notes that apply from higher levels

Instructions written at a parent level also apply to D57.21.

› From D57 Sickle-cell disorders
Excludes1
  • other hemoglobinopathies (D58.-)
Use additional code
  • code for any associated fever (R50.81)

Broader instructions also apply from Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about D57.21

Is D57.21 billable?

No. D57.21 is a header code. Report one of its more specific subcodes instead.