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ICD-10-CM 2027 diagnosis code

D57Sickle-cell disorders

Not billable — use a more specific code

D57 is a header code, so it can't be reported by itself. Choose one of the 6 more specific codes beneath it.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About D57

D57 is the ICD-10-CM diagnosis code for sickle-cell disorders. It belongs to block D55-D59 (hemolytic anemias) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is a header code, so it can't be reported by itself; one of its 6 subcodes must be used instead.

To report this condition, pick the subcode that matches the documentation: D57.0 (crisis), D57.1 (crisis), D57.2 (disease), D57.3 (trait), D57.4 (thalassemia) and D57.8 (disorders).

Don't report D57 together with the conditions in its Excludes1 note: other hemoglobinopathies (D58.-).

Use an additional code for any associated fever (R50.81).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Specific codes under D57

Coding notes

Excludes1Not coded here — never report together with this code
  • other hemoglobinopathies (D58.-)
Use additional codeAdd a secondary code to fully describe the condition
  • code for any associated fever (R50.81)

Notes that apply from higher levels

Instructions written at a parent level also apply to D57.

Broader instructions also apply from Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism.

Alphabetic index entries

7 entries

Terms in the official ICD-10-CM index that lead to D57.

Codes whose notes reference D57

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about D57

Is D57 billable?

No. D57 is a header code. Report one of its more specific subcodes instead.