Skip to content
Dx

ICD-10-CM 2027 diagnosis code

D57.211Sickle-cell/Hb-C disease with acute chest syndrome

✓ Billable / specificMCC — major complication/comorbidity

D57.211 is a valid, billable ICD-10-CM code for sickle-cell/hb-c disease with acute chest syndrome. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About D57.211

D57.211 is the ICD-10-CM diagnosis code for Sickle-cell/Hb-C disease with acute chest syndrome. It belongs to category D57 (sickle-cell disorders), block D55-D59 (hemolytic anemias) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within D57.21 (Sickle-cell/Hb-C disease with crisis), D57.211 is specifically for Sickle-cell/Hb-C disease with acute chest syndrome. Related codes cover splenic sequestration (D57.212), cerebral vascular involvement (D57.213), dactylitis (D57.214), with other specified complication (D57.218) and unspecified (D57.219).

Use an additional code for any associated fever (R50.81).

As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 811 (Red Blood Cell Disorders with MCC, relative weight 1.3988) and DRG 812 (Red Blood Cell Disorders without MCC, relative weight 0.9234), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 282.64 (Sickle-cell/Hb-C disease with crisis) and 517.3 (acute chest syndrome).

Notes that apply from higher levels

Instructions written at a parent level also apply to D57.211.

› From D57 Sickle-cell disorders
Excludes1
  • other hemoglobinopathies (D58.-)
Use additional code
  • code for any associated fever (R50.81)

Broader instructions also apply from Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism.

Alphabetic index entries

1 entries

Terms in the official ICD-10-CM index that lead to D57.211.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

MDC 16 · Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders

ICD-9-CM equivalent

Converter →
  • 282.64Sickle-cell/Hb-C disease with crisisapproximate, combination
  • 517.3Acute chest syndromeapproximate, combination

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about D57.211

Is D57.211 billable?

Yes. D57.211 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can D57.211 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict D57.211 as a principal diagnosis.

Is D57.211 a CC or MCC?

D57.211 is an MCC (major complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.

What DRG does D57.211 group to?

D57.211 is used in the MS-DRG v44.0 logic for MS-DRG 811 (Red Blood Cell Disorders with MCC) and MS-DRG 812 (Red Blood Cell Disorders without MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for D57.211?

The CMS General Equivalence Mappings map D57.211 to ICD-9-CM 282.64 and 517.3.