ICD-10-CM 2027 diagnosis code
D89Other disorders involving the immune mechanism, not elsewhere classified
D89 is a header code, so it can't be reported by itself. Choose one of the 7 more specific codes beneath it.Short description: Oth disorders involving the immune mechanism, NEC
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About D89
D89 is the ICD-10-CM diagnosis code for other disorders involving the immune mechanism, not elsewhere classified. It belongs to block D80-D89 (certain disorders involving the immune mechanism) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is a header code, so it can't be reported by itself; one of its 7 subcodes must be used instead.
To report this condition, pick the subcode that matches the documentation: D89.0 (hypergammaglobulinemia), D89.1 (Cryoglobulinemia), D89.2 (unspecified), D89.3 (syndrome), D89.4 (disorders), D89.8 (classified) and D89.9 (unspecified).
Don't report D89 together with the conditions in its Excludes1 note: hyperglobulinemia NOS (R77.1) and monoclonal gammopathy (of undetermined significance) (D47.2).
The conditions in its Excludes2 note aren't part of D89, but may be coded alongside it if the patient has both: transplant failure and rejection (T86.-).
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Specific codes under D89
- D89.0Polyclonal hypergammaglobulinemiaBillable
- D89.1CryoglobulinemiaBillable
- D89.2Hypergammaglobulinemia, unspecifiedBillable
- D89.3Immune reconstitution syndromeBillable
- D89.4Mast cell activation syndrome and related disorders
- D89.8Other specified disorders involving the immune mechanism, not elsewhere classified
- D89.81Graft-versus-host disease
- D89.82Autoimmune lymphoproliferative syndrome [ALPS]Billable
- D89.83Cytokine release syndrome
- D89.831Cytokine release syndrome, grade 1Billable
- D89.832Cytokine release syndrome, grade 2Billable
- D89.833Cytokine release syndrome, grade 3Billable
- D89.834Cytokine release syndrome, grade 4Billable
- D89.835Cytokine release syndrome, grade 5Billable
- D89.839Cytokine release syndrome, grade unspecifiedBillable
- D89.84IgG4-related diseaseBillable
- D89.89Other specified disorders involving the immune mechanism, not elsewhere classifiedBillable
- D89.9Disorder involving the immune mechanism, unspecifiedBillable
Coding notes
Notes that apply from higher levels
Instructions written at a parent level also apply to D89.
Broader instructions also apply from D80-D89 Certain disorders involving the immune mechanism and Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism.
Codes whose notes reference D89
- D72Excludes1
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about D89
Is D89 billable?
- No. D89 is a header code. Report one of its more specific subcodes instead.