E03.2Hypothyroidism due to medicaments and other exogenous substances

E03.2 is the ICD-10-CM diagnosis code for hypothyroidism due to medicaments and other exogenous substances. It belongs to category E03 (other hypothyroidism), block E00-E07 (disorders of thyroid gland) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E03, choose E03.2 (Hypothyroidism due to medicaments and other exogenous substances) only when documentation doesn't support a more specific option: congenital hypothyroidism with diffuse goiter (E03.0), congenital hypothyroidism without goiter (E03.1), postinfectious hypothyroidism (E03.3), atrophy of thyroid (acquired) (E03.4), myxedema coma (E03.5), other specified hypothyroidism (E03.8) and hypothyroidism, unspecified (E03.9).

Code first: poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4).

Use an additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 244.2 (Iodine hypothyroidism) and 244.3 (other iatrogenic hypothyroidism).