ICD-10-CM 2027 diagnosis code
E34.321Primary insulin-like growth factor-1 (IGF-1) deficiency
E34.321 is a valid, billable ICD-10-CM code for primary insulin-like growth factor-1 (igf-1) deficiency. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.
Code last changed in FY2023 (effective October 1, 2022). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About E34.321
E34.321 is the ICD-10-CM diagnosis code for primary insulin-like growth factor-1 (IGF-1) deficiency. It belongs to category E34 (other endocrine disorders), block E20-E35 (disorders of other endocrine glands) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within E34.32 (genetic causes of short stature), E34.321 is specifically for primary insulin-like growth factor-1 (IGF-1) deficiency. Related codes cover insulin-like growth factor-1 (IGF-1) resistance (E34.322), other genetic causes of short stature (E34.328) and unspecified genetic causes of short stature (E34.329).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It was added in FY2023, effective October 1, 2022.
Coding notes
- Acid-labile subunit gene (IGFALS) defect
- Growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies
- Growth hormone insensitivity syndrome (GHIS)
- Insulin-like growth factor 1 gene (IGF1) defect
- Laron type short stature
- Severe primary insulin-like growth factor-1 deficiency (SPIGFD)
- Signal transducer and activator of transcription 5B gene (STAT5b) defect
Notes that apply from higher levels
Instructions written at a parent level also apply to E34.321.
› From E34.3 Short stature due to endocrine disorder
- achondroplastic short stature (Q77.4)
- hypochondroplastic short stature (Q77.4)
- nutritional short stature (E45)
- pituitary short stature (E23.0)
- progeria (E34.8)
- renal short stature (N25.0)
- Russell-Silver syndrome (Q87.19)
- short-limbed stature with immunodeficiency (D82.2)
- short stature (child) (R62.52)
- short stature in specific dysmorphic syndromes - code to syndrome - see Alphabetical Index
- short stature NOS (R62.52)
› From E34 Other endocrine disorders
- pseudohypoparathyroidism (E20.1)
Broader instructions also apply from E20-E35 Disorders of other endocrine glands and Chapter 4: Endocrine, nutritional and metabolic diseases.
Alphabetic index entries
9 entriesTerms in the official ICD-10-CM index that lead to E34.321.
- Dwarfism › Laron-type
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › due to › genetic causes › acid-labile subunit gene (IGFALS) defect
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › due to › genetic causes › growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › due to › genetic causes › growth hormone insensitivity syndrome (GHIS)
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › due to › genetic causes › insulin-like growth factor 1 gene (IGF1) defect
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › due to › genetic causes › primary insulin-like growth factor-1 (IGF-1) deficiency
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › due to › genetic causes › severe primary insulin-like growth factor-1 deficiency (SPIGFD)
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › due to › genetic causes › signal transducer and activator of transcription 5B gene (STAT5b) defect
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › Laron-type
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 10 · Endocrine, Nutritional and Metabolic Diseases and Disorders
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2023 (effective 10/1/2022): Added
- No changes since FY2023.
Common questions about E34.321
Is E34.321 billable?
- Yes. E34.321 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E34.321 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E34.321 as a principal diagnosis.
Is E34.321 a CC or MCC?
- No. E34.321 is neither a CC nor an MCC under MS-DRG v44.0.
What DRG does E34.321 group to?
- E34.321 is used in the MS-DRG v44.0 logic for MS-DRG 643 (Endocrine Disorders with MCC), MS-DRG 644 (Endocrine Disorders with CC) and MS-DRG 645 (Endocrine Disorders without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.