ICD-10-CM 2027 diagnosis code
E34.322Insulin-like growth factor-1 (IGF-1) resistance
E34.322 is a valid, billable ICD-10-CM code for insulin-like growth factor-1 (igf-1) resistance. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.
Code last changed in FY2023 (effective October 1, 2022). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About E34.322
E34.322 is the ICD-10-CM diagnosis code for insulin-like growth factor-1 (IGF-1) resistance. It belongs to category E34 (other endocrine disorders), block E20-E35 (disorders of other endocrine glands) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within E34.32 (genetic causes of short stature), E34.322 is specifically for insulin-like growth factor-1 (IGF-1) resistance. Related codes cover primary insulin-like growth factor-1 (IGF-1) deficiency (E34.321), other genetic causes of short stature (E34.328) and unspecified genetic causes of short stature (E34.329).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It was added in FY2023, effective October 1, 2022.
Coding notes
- Genetic syndrome with resistance to insulin-like growth factor-1
- Insulin-like growth factor-1 receptor (IGF-1R) defect
- Post-insulin-like growth factor-1 receptor signaling defect
Notes that apply from higher levels
Instructions written at a parent level also apply to E34.322.
› From E34.3 Short stature due to endocrine disorder
- achondroplastic short stature (Q77.4)
- hypochondroplastic short stature (Q77.4)
- nutritional short stature (E45)
- pituitary short stature (E23.0)
- progeria (E34.8)
- renal short stature (N25.0)
- Russell-Silver syndrome (Q87.19)
- short-limbed stature with immunodeficiency (D82.2)
- short stature (child) (R62.52)
- short stature in specific dysmorphic syndromes - code to syndrome - see Alphabetical Index
- short stature NOS (R62.52)
› From E34 Other endocrine disorders
- pseudohypoparathyroidism (E20.1)
Broader instructions also apply from E20-E35 Disorders of other endocrine glands and Chapter 4: Endocrine, nutritional and metabolic diseases.
Alphabetic index entries
4 entriesTerms in the official ICD-10-CM index that lead to E34.322.
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › due to › genetic causes › genetic syndrome with resistance to insulin-like growth factor-1
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › due to › genetic causes › insulin-like growth factor-1 receptor (IGF-1R) defect
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › due to › genetic causes › insulin-like growth factor-1 (IGF-1) resistance
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › due to › genetic causes › post-insulin-like growth factor-1 receptor signaling defect
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 10 · Endocrine, Nutritional and Metabolic Diseases and Disorders
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2023 (effective 10/1/2022): Added
- No changes since FY2023.
Common questions about E34.322
Is E34.322 billable?
- Yes. E34.322 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E34.322 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E34.322 as a principal diagnosis.
Is E34.322 a CC or MCC?
- No. E34.322 is neither a CC nor an MCC under MS-DRG v44.0.
What DRG does E34.322 group to?
- E34.322 is used in the MS-DRG v44.0 logic for MS-DRG 643 (Endocrine Disorders with MCC), MS-DRG 644 (Endocrine Disorders with CC) and MS-DRG 645 (Endocrine Disorders without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.