ICD-10-CM 2027 diagnosis code

Z15Genetic susceptibility to disease

Not billable — use a more specific code

Z15 is a header code, so it can't be reported by itself. Choose one of the 5 more specific codes beneath it.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About Z15

Z15 is the ICD-10-CM diagnosis code for genetic susceptibility to disease. It belongs to block Z14-Z15 (genetic carrier and genetic susceptibility to disease) and chapter 21 (factors influencing health status and contact with health services). It is a header code, so it can't be reported by itself; one of its 5 subcodes must be used instead.

To report this condition, pick the subcode that matches the documentation: Z15.0 (neoplasm), Z15.1 (disorders), Z15.2 (obesity), Z15.3 (disease) and Z15.8 (disease).

Don't report Z15 together with the conditions in its Excludes1 note: chromosomal anomalies (Q90-Q99).

Use an additional code, if applicable, for any associated family history of the disease (Z80-Z84).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Specific codes under Z15

Coding notes

IncludesFurther defines the content of the category

confirmed abnormal gene

Excludes1Not coded here — never report together with this code

chromosomal anomalies (Q90-Q99)

Use additional codeAdd a secondary code to fully describe the condition

code, if applicable, for any associated family history of the disease (Z80-Z84)

Notes that apply from higher levels

Instructions written at a parent level also apply to Z15.

Broader instructions also apply from Chapter 21: Factors influencing health status and contact with health services.

Codes whose notes reference Z15

Z40.0Use additional code

Code history

2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
2027

FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
No changes since FY2016.

Common questions about Z15

Is Z15 billable?: No. Z15 is a header code. Report one of its more specific subcodes instead.