Z15.068Genetic susceptibility to other malignant neoplasm of digestive system

Z15.068 is the ICD-10-CM diagnosis code for genetic susceptibility to other malignant neoplasm of digestive system. It belongs to category Z15 (genetic susceptibility to disease), block Z14-Z15 (genetic carrier and genetic susceptibility to disease) and chapter 21 (factors influencing health status and contact with health services). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within Z15.06, choose Z15.068 (other malignant neoplasm of digestive system) only when documentation doesn't support a more specific option: colorectal cancer (Z15.060).

Use an additional code, if applicable, for any associated family history of the disease (Z80-Z84).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 951 (Other Factors Influencing Health Status, relative weight 0.5577), in MDC 23 (Factors Influencing Health Status and Other Contacts with Health Services), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.

It is exempt from present-on-admission (POA) reporting, so no POA indicator is required.

It was added in FY2026, effective October 1, 2025.