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ICD-10-CM 2027 diagnosis code

Z15.3Genetic susceptibility to kidney disease

✓ Billable / specificPOA exemptNot a principal dx

Z15.3 is a valid, billable ICD-10-CM code for genetic susceptibility to kidney disease. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Code last changed in FY2026 (effective October 1, 2025). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About Z15.3

Z15.3 is the ICD-10-CM diagnosis code for genetic susceptibility to kidney disease. It belongs to category Z15 (genetic susceptibility to disease), block Z14-Z15 (genetic carrier and genetic susceptibility to disease) and chapter 21 (factors influencing health status and contact with health services). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within Z15 (genetic susceptibility to disease), Z15.3 is specifically for genetic susceptibility to kidney disease. Related codes cover malignant neoplasm (Z15.0), epilepsy and neurodevelopmental disorders (Z15.1), obesity (Z15.2) and other disease (Z15.8).

Use an additional code, if applicable, for any associated family history of the disease (Z80-Z84).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 951 (Other Factors Influencing Health Status, relative weight 0.5577), in MDC 23 (Factors Influencing Health Status and Other Contacts with Health Services), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.

It is exempt from present-on-admission (POA) reporting, so no POA indicator is required.

It was added in FY2026, effective October 1, 2025.

Coding notes

Code alsoTwo codes may be needed; sequencing depends on circumstances
  • , if applicable, hypertension (I10-I1A)

Notes that apply from higher levels

Instructions written at a parent level also apply to Z15.3.

› From Z15 Genetic susceptibility to disease
Includes
  • confirmed abnormal gene
Excludes1
  • chromosomal anomalies (Q90-Q99)
Use additional code
  • code, if applicable, for any associated family history of the disease (Z80-Z84)

Broader instructions also apply from Chapter 21: Factors influencing health status and contact with health services.

Alphabetic index entries

1 entries

Terms in the official ICD-10-CM index that lead to Z15.3.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

MDC 23 · Factors Influencing Health Status and Other Contacts with Health Services

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2026 (effective 10/1/2025): Added
  • No changes since FY2026.

Common questions about Z15.3

Is Z15.3 billable?

Yes. Z15.3 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can Z15.3 be used as a principal diagnosis?

No. It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.

Is Z15.3 a CC or MCC?

No. Z15.3 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does Z15.3 group to?

Z15.3 is used in the MS-DRG v44.0 logic for MS-DRG 951 (Other Factors Influencing Health Status). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.