Z79.81Long term (current) use of agents affecting estrogen receptors and estrogen levels

Z79.81 is the ICD-10-CM diagnosis code for long term (current) use of agents affecting estrogen receptors and estrogen levels. It belongs to category Z79 (long term (current) drug therapy), block Z77-Z99 (persons with potential health hazards related to family and personal history and certain conditions influencing health status) and chapter 21 (factors influencing health status and contact with health services). It is a header code, so it can't be reported by itself; one of its 3 subcodes must be used instead.

Within Z79.8 (other long term (current) drug therapy), Z79.81 is specifically for long term (current) use of agents affecting estrogen receptors and estrogen levels. Related codes cover long term (current) use of aspirin (Z79.82), long term (current) use of bisphosphonates (Z79.83), long term (current) use of oral hypoglycemic drugs (Z79.84), Long-term (current) use of injectable non-insulin antidiabetic drugs (Z79.85) and other long term (current) drug therapy (Z79.89).

To report this condition, pick the subcode that matches the documentation: Z79.810 ((SERMs)), Z79.811 (inhibitors) and Z79.818 (levels).

Don't report Z79.81 together with the conditions in its Excludes1 note: hormone replacement therapy (Z79.890).

Code first , if applicable: malignant neoplasm of breast (C50.-) and malignant neoplasm of prostate (C61).

Use an additional code, if applicable, to identify: estrogen receptor positive status (Z17.0), family history of breast cancer (Z80.3), genetic susceptibility to malignant neoplasm (cancer) (Z15.0-), personal history of breast cancer (Z85.3), personal history of prostate cancer (Z85.46) and 1 more.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.