D46.BRefractory cytopenia with multilineage dysplasia and ring sideroblasts

D46.B is the ICD-10-CM diagnosis code for refractory cytopenia with multilineage dysplasia and ring sideroblasts. It belongs to category D46 (myelodysplastic syndromes), block D37-D48 (neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes) and chapter 2 (neoplasms). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within D46 (myelodysplastic syndromes), D46.B is specifically for refractory cytopenia with multilineage dysplasia and ring sideroblasts. Related codes cover refractory anemia without ring sideroblasts, so stated (D46.0), refractory anemia with ring sideroblasts (D46.1), refractory anemia with excess of blasts [RAEB] (D46.2), refractory anemia, unspecified (D46.4), myelodysplastic syndrome, unspecified (D46.9), refractory cytopenia with multilineage dysplasia (D46.A), myelodysplastic syndrome with isolated del(5q) chromosomal abnormality (D46.C) and other myelodysplastic syndromes (D46.Z).

Use an additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 811 (Red Blood Cell Disorders with MCC, relative weight 1.3988) and DRG 812 (Red Blood Cell Disorders without MCC, relative weight 0.9234), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 238.72 (low grade myelodysplastic syndrome lesions).