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ICD-10-CM 2027 diagnosis code

D46.CMyelodysplastic syndrome with isolated del(5q) chromosomal abnormality

✓ Billable / specificCC — complication/comorbidity

D46.C is a valid, billable ICD-10-CM code for myelodysplastic syndrome with isolated del(5q) chromosomal abnormality. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.Short description: Myelodysplastic syndrome w isolated del(5q) chromsoml abnlt

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About D46.C

D46.C is the ICD-10-CM diagnosis code for myelodysplastic syndrome with isolated del(5q) chromosomal abnormality. It belongs to category D46 (myelodysplastic syndromes), block D37-D48 (neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes) and chapter 2 (neoplasms). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within D46 (myelodysplastic syndromes), D46.C is specifically for myelodysplastic syndrome with isolated del(5q) chromosomal abnormality. Related codes cover refractory anemia without ring sideroblasts, so stated (D46.0), refractory anemia with ring sideroblasts (D46.1), refractory anemia with excess of blasts [RAEB] (D46.2), refractory anemia, unspecified (D46.4), myelodysplastic syndrome, unspecified (D46.9), refractory cytopenia with multilineage dysplasia (D46.A), refractory cytopenia with multilineage dysplasia and ring sideroblasts (D46.B) and other myelodysplastic syndromes (D46.Z).

Use an additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 811 (Red Blood Cell Disorders with MCC, relative weight 1.3988) and DRG 812 (Red Blood Cell Disorders without MCC, relative weight 0.9234), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 238.74 (myelodysplastic syndrome with 5q deletion).

Coding notes

Applicable toConditions and synonyms classified to this code
  • Myelodysplastic syndrome with 5q deletion
  • 5q minus syndrome NOS

Notes that apply from higher levels

Instructions written at a parent level also apply to D46.C.

› From D46 Myelodysplastic syndromes
Excludes2
  • drug-induced aplastic anemia (D61.1)
Use additional code
  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Broader instructions also apply from D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes and Chapter 2: Neoplasms.

Alphabetic index entries

5 entries

Terms in the official ICD-10-CM index that lead to D46.C.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

MDC 16 · Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders

ICD-9-CM equivalent

Converter →
  • 238.74Myelodysplastic syndrome with 5q deletionexact

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about D46.C

Is D46.C billable?

Yes. D46.C is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can D46.C be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict D46.C as a principal diagnosis.

Is D46.C a CC or MCC?

D46.C is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.

What DRG does D46.C group to?

D46.C is used in the MS-DRG v44.0 logic for MS-DRG 811 (Red Blood Cell Disorders with MCC) and MS-DRG 812 (Red Blood Cell Disorders without MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for D46.C?

The CMS General Equivalence Mappings map D46.C to ICD-9-CM 238.74.