D55.2Anemia due to disorders of glycolytic enzymes

D55.2 is the ICD-10-CM diagnosis code for anemia due to disorders of glycolytic enzymes. It belongs to category D55 (anemia due to enzyme disorders), block D55-D59 (hemolytic anemias) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is a header code, so it can't be reported by itself; one of its 2 subcodes must be used instead.

Within D55 (anemia due to enzyme disorders), D55.2 is specifically for anemia due to disorders of glycolytic enzymes. Related codes cover anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency (D55.0), anemia due to other disorders of glutathione metabolism (D55.1), anemia due to disorders of nucleotide metabolism (D55.3), other anemias due to enzyme disorders (D55.8) and anemia due to enzyme disorder, unspecified (D55.9).

To report this condition, pick the subcode that matches the documentation: D55.21 (deficiency) and D55.29 (enzymes).

Don't report D55.2 together with the conditions in its Excludes1 note: disorders of glycolysis not associated with anemia (E74.81-).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015, and changed in FY2022 (expanded into subcodes).

Before ICD-10, this condition was coded in ICD-9-CM as 282.3 (other hemolytic anemias due to enzyme deficiency).