D55.9Anemia due to enzyme disorder, unspecified

D55.9 is the ICD-10-CM diagnosis code for anemia due to enzyme disorder, unspecified. It belongs to category D55 (anemia due to enzyme disorders), block D55-D59 (hemolytic anemias) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within D55, choose D55.9 (Anemia due to enzyme disorder, unspecified) only when documentation doesn't support a more specific option: anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency (D55.0), anemia due to other disorders of glutathione metabolism (D55.1), anemia due to disorders of glycolytic enzymes (D55.2), anemia due to disorders of nucleotide metabolism (D55.3) and other anemias due to enzyme disorders (D55.8).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 811 (Red Blood Cell Disorders with MCC, relative weight 1.3988) and DRG 812 (Red Blood Cell Disorders without MCC, relative weight 0.9234), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 282.3 (other hemolytic anemias due to enzyme deficiency).