ICD-10-CM 2027 diagnosis code
D89.1Cryoglobulinemia
D89.1 is a valid, billable ICD-10-CM code for cryoglobulinemia. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.
Looking up by condition? See ICD-10 code for Cryoglobulinemia.
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About D89.1
D89.1 is the ICD-10-CM diagnosis code for Cryoglobulinemia. It belongs to category D89 (other disorders involving the immune mechanism, not elsewhere classified), block D80-D89 (certain disorders involving the immune mechanism) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within D89 (other disorders involving the immune mechanism, not elsewhere classified), D89.1 is specifically for Cryoglobulinemia. Related codes cover Polyclonal hypergammaglobulinemia (D89.0), hypergammaglobulinemia, unspecified (D89.2), immune reconstitution syndrome (D89.3), mast cell activation syndrome and related disorders (D89.4), other specified disorders involving the immune mechanism, not elsewhere classified (D89.8) and disorder involving the immune mechanism, unspecified (D89.9).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 820 (Lymphoma and Leukemia with Major O.R. Procedures with MCC, relative weight 6.2481), DRG 821 (Lymphoma and Leukemia with Major O.R. Procedures with CC, relative weight 2.2023), DRG 822 (Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC, relative weight 1.1272), DRG 823 (Lymphoma and Non-Acute Leukemia with Other Procedures with MCC, relative weight 4.6059), DRG 824 (Lymphoma and Non-Acute Leukemia with Other Procedures with CC, relative weight 2.2515), DRG 825 (Lymphoma and Non-Acute Leukemia with Other Procedures without CC/MCC, relative weight 1.2995) and 3 more, in MDC 17 (Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Before ICD-10, this condition was coded in ICD-9-CM as 273.2 (other paraproteinemias).
Coding notes
- Cryoglobulinemic purpura
- Cryoglobulinemic vasculitis
- Essential cryoglobulinemia
- Idiopathic cryoglobulinemia
- Mixed cryoglobulinemia
- Primary cryoglobulinemia
- Secondary cryoglobulinemia
Notes that apply from higher levels
Instructions written at a parent level also apply to D89.1.
Alphabetic index entries
9 entriesTerms in the official ICD-10-CM index that lead to D89.1.
- Cryoglobulinemia (essential) (idiopathic) (mixed) (primary) (purpura) (secondary) (vasculitis)
- Cryoglobulinemia (essential) (idiopathic) (mixed) (primary) (purpura) (secondary) (vasculitis) › with lung involvement
- Disorder (of) › glomerular (in) › cryoglobulinemia
- Disorder (of) › tubulo-interstitial (in) › mixed cryoglobulinemia
- Glomerulonephritis › in (due to) › cryoglobulinemia
- Nephritis, nephritic (albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic) › tubulo-interstitial (in) › due to › cryoglobulinemia
- Purpura › cryoglobulinemic
- Pyelonephritis › in (due to) › cryoglobulinemia (mixed)
- Vasculitis › cryoglobulinemic
Codes whose notes reference D89.1
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 17 · Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms
MDC 17 · Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms
MDC 17 · Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms
ICD-9-CM equivalent
Converter →- 273.2Other paraproteinemiasexact
From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about D89.1
Is D89.1 billable?
- Yes. D89.1 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D89.1 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D89.1 as a principal diagnosis.
Is D89.1 a CC or MCC?
- No. D89.1 is neither a CC nor an MCC under MS-DRG v44.0.
What DRG does D89.1 group to?
- D89.1 is used in the MS-DRG v44.0 logic for MS-DRG 820 (Lymphoma and Leukemia with Major O.R. Procedures with MCC), MS-DRG 821 (Lymphoma and Leukemia with Major O.R. Procedures with CC), MS-DRG 822 (Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC), MS-DRG 823 (Lymphoma and Non-Acute Leukemia with Other Procedures with MCC), MS-DRG 824 (Lymphoma and Non-Acute Leukemia with Other Procedures with CC), MS-DRG 825 (Lymphoma and Non-Acute Leukemia with Other Procedures without CC/MCC) and 3 more. Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.
What is the ICD-9 code for D89.1?
- The CMS General Equivalence Mappings map D89.1 to ICD-9-CM 273.2.