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ICD-10-CM 2027 diagnosis code

E23.3Hypothalamic dysfunction, not elsewhere classified

✓ Billable / specific

E23.3 is a valid, billable ICD-10-CM code for hypothalamic dysfunction, not elsewhere classified. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Looking up by condition? See ICD-10 code for Dyspituitarism, ICD-10 code for Renon-Delille syndrome.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E23.3

E23.3 is the ICD-10-CM diagnosis code for hypothalamic dysfunction, not elsewhere classified. It belongs to category E23 (hypofunction and other disorders of the pituitary gland), block E20-E35 (disorders of other endocrine glands) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E23 (hypofunction and other disorders of the pituitary gland), E23.3 is specifically for hypothalamic dysfunction, not elsewhere classified. Related codes cover hypopituitarism (E23.0), drug-induced hypopituitarism (E23.1), diabetes insipidus (E23.2), other disorders of pituitary gland (E23.6) and disorder of pituitary gland, unspecified (E23.7).

Don't report E23.3 together with the conditions in its Excludes1 note: Prader-Willi syndrome (Q87.11) and Russell-Silver syndrome (Q87.19).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 253.9 (unspecified disorder of the pituitary gland and its hypothalamic control).

Coding notes

Excludes1Not coded here — never report together with this code
  • Prader-Willi syndrome (Q87.11)
  • Russell-Silver syndrome (Q87.19)

Notes that apply from higher levels

Instructions written at a parent level also apply to E23.3.

› From E23 Hypofunction and other disorders of the pituitary gland
Includes
  • the listed conditions whether the disorder is in the pituitary or the hypothalamus
Excludes1
  • postprocedural hypopituitarism (E89.3)
  • short stature due to endocrine disorder (E34.3-)

Broader instructions also apply from E20-E35 Disorders of other endocrine glands and Chapter 4: Endocrine, nutritional and metabolic diseases.

Alphabetic index entries

6 entries

Terms in the official ICD-10-CM index that lead to E23.3.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

ICD-9-CM equivalent

Converter →
  • 253.9Unspecified disorder of the pituitary gland and its hypothalamic controlapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about E23.3

Is E23.3 billable?

Yes. E23.3 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can E23.3 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict E23.3 as a principal diagnosis.

Is E23.3 a CC or MCC?

No. E23.3 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does E23.3 group to?

E23.3 is used in the MS-DRG v44.0 logic for MS-DRG 643 (Endocrine Disorders with MCC), MS-DRG 644 (Endocrine Disorders with CC) and MS-DRG 645 (Endocrine Disorders without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for E23.3?

The CMS General Equivalence Mappings map E23.3 to ICD-9-CM 253.9.