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ICD-10-CM 2027 diagnosis code

E77.0Defects in post-translational modification of lysosomal enzymes

✓ Billable / specific

E77.0 is a valid, billable ICD-10-CM code for defects in post-translational modification of lysosomal enzymes. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.Short description: Defects in post-translational mod of lysosomal enzymes

Looking up by condition? See ICD-10 code for Polydystrophy, ICD-10 code for Pseudo-Hurler's polydystrophy.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E77.0

E77.0 is the ICD-10-CM diagnosis code for defects in post-translational modification of lysosomal enzymes. It belongs to category E77 (disorders of glycoprotein metabolism), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E77 (disorders of glycoprotein metabolism), E77.0 is specifically for defects in post-translational modification of lysosomal enzymes. Related codes cover defects in glycoprotein degradation (E77.1), other disorders of glycoprotein metabolism (E77.8) and disorder of glycoprotein metabolism, unspecified (E77.9).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 272.7 (lipidoses).

Coding notes

Applicable toConditions and synonyms classified to this code
  • Mucolipidosis II [I-cell disease]
  • Mucolipidosis III [pseudo-Hurler polydystrophy]

Notes that apply from higher levels

Instructions written at a parent level also apply to E77.0.

Broader instructions also apply from E70-E88 Metabolic disorders and Chapter 4: Endocrine, nutritional and metabolic diseases.

Alphabetic index entries

7 entries

Terms in the official ICD-10-CM index that lead to E77.0.

Codes whose notes reference E77.0

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

MDC 10 · Endocrine, Nutritional and Metabolic Diseases and Disorders

ICD-9-CM equivalent

Converter →
  • 272.7Lipidosesapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about E77.0

Is E77.0 billable?

Yes. E77.0 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can E77.0 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict E77.0 as a principal diagnosis.

Is E77.0 a CC or MCC?

No. E77.0 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does E77.0 group to?

E77.0 is used in the MS-DRG v44.0 logic for MS-DRG 642 (Inborn and Other Disorders of Metabolism). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for E77.0?

The CMS General Equivalence Mappings map E77.0 to ICD-9-CM 272.7.