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ICD-10-CM 2027 diagnosis code

E88Other and unspecified metabolic disorders

Not billable — use a more specific code

E88 is a header code, so it can't be reported by itself. Choose one of the 8 more specific codes beneath it.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E88

E88 is the ICD-10-CM diagnosis code for other and unspecified metabolic disorders. It belongs to block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is a header code, so it can't be reported by itself; one of its 8 subcodes must be used instead.

To report this condition, pick the subcode that matches the documentation: E88.0 (classified), E88.1 (classified), E88.2 (classified), E88.3 (syndrome), E88.4 (disorders), E88.8 (disorders), E88.9 (unspecified) and E88.A (condition).

Don't report E88 together with the conditions in its Excludes1 note: histiocytosis X (chronic) (C96.6).

Use an additional code for: codes for associated conditions.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Specific codes under E88

Coding notes

Excludes1Not coded here — never report together with this code
  • histiocytosis X (chronic) (C96.6)
Use additional codeAdd a secondary code to fully describe the condition
  • codes for associated conditions

Notes that apply from higher levels

Instructions written at a parent level also apply to E88.

Broader instructions also apply from E70-E88 Metabolic disorders and Chapter 4: Endocrine, nutritional and metabolic diseases.

Codes whose notes reference E88

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about E88

Is E88 billable?

No. E88 is a header code. Report one of its more specific subcodes instead.