ICD-10-CM 2027 diagnosis code
E75Disorders of sphingolipid metabolism and other lipid storage disorders
E75 is a header code, so it can't be reported by itself. Choose one of the 7 more specific codes beneath it.Short description: Disord of sphingolipid metab and oth lipid storage disorders
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About E75
E75 is the ICD-10-CM diagnosis code for disorders of sphingolipid metabolism and other lipid storage disorders. It belongs to block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is a header code, so it can't be reported by itself; one of its 7 subcodes must be used instead.
To report this condition, pick the subcode that matches the documentation: E75.0 (gangliosidosis), E75.1 (gangliosidosis), E75.2 (sphingolipidosis), E75.3 (unspecified), E75.4 (lipofuscinosis), E75.5 (disorders) and E75.6 (unspecified).
Don't report E75 together with the conditions in its Excludes1 note: mucolipidosis, types I-III (E77.0-E77.1) and Refsum's disease (G60.1).
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Specific codes under E75
- E75.0GM2 gangliosidosis
- E75.1Other and unspecified gangliosidosis
- E75.2Other sphingolipidosis
- E75.21Fabry (-Anderson) diseaseBillable
- E75.22Gaucher diseaseBillable
- E75.23Krabbe diseaseBillable
- E75.24Niemann-Pick disease
- E75.240Niemann-Pick disease type ABillable
- E75.241Niemann-Pick disease type BBillable
- E75.242Niemann-Pick disease type CBillable
- E75.243Niemann-Pick disease type DBillable
- E75.244Niemann-Pick disease type A/BBillable
- E75.248Other Niemann-Pick diseaseBillable
- E75.249Niemann-Pick disease, unspecifiedBillable
- E75.25Metachromatic leukodystrophyBillable
- E75.26Sulfatase deficiencyBillable
- E75.27Pelizaeus-Merzbacher diseaseBillable
- E75.28Canavan diseaseBillable
- E75.29Other sphingolipidosisBillable
- E75.3Sphingolipidosis, unspecifiedBillable
- E75.4Neuronal ceroid lipofuscinosisBillable
- E75.5Other lipid storage disordersBillable
- E75.6Lipid storage disorder, unspecifiedBillable
Coding notes
Notes that apply from higher levels
Instructions written at a parent level also apply to E75.
Broader instructions also apply from E70-E88 Metabolic disorders and Chapter 4: Endocrine, nutritional and metabolic diseases.
Alphabetic index entries
2 entriesTerms in the official ICD-10-CM index that lead to E75.
- Dementia (degenerative (primary)) (persisting) (unspecified severity) (without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety) › in (due to) › cerebral lipidoses
- Dementia (degenerative (primary)) (persisting) (unspecified severity) (without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety) › in (due to) › cerebral lipidoses › with behavioral disturbance
Codes whose notes reference E75
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about E75
Is E75 billable?
- No. E75 is a header code. Report one of its more specific subcodes instead.