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ICD-10-CM 2027 diagnosis code

E88.02Plasminogen deficiency

✓ Billable / specificCC — complication/comorbidity

E88.02 is a valid, billable ICD-10-CM code for plasminogen deficiency. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Looking up by condition? See ICD-10 code for Dysplasminogenemia, ICD-10 code for Hypoplasminogenemia.

Code last changed in FY2019 (effective October 1, 2018). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E88.02

E88.02 is the ICD-10-CM diagnosis code for Plasminogen deficiency. It belongs to category E88 (other and unspecified metabolic disorders), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E88.0 (disorders of plasma-protein metabolism, not elsewhere classified), E88.02 is specifically for Plasminogen deficiency. Related codes cover Alpha-1-antitrypsin deficiency (E88.01) and other disorders of plasma-protein metabolism, not elsewhere classified (E88.09).

Use an additional code for associated findings, such as: hydrocephalus (G91.4), otitis media (H67.-), respiratory disorder related to plasminogen deficiency (J99) and codes for associated conditions.

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 826 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with MCC, relative weight 4.7581), DRG 827 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with CC, relative weight 2.3896), DRG 828 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures without CC/MCC, relative weight 1.6955), DRG 829 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures with CC/MCC, relative weight 3.1281), DRG 830 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures without CC/MCC, relative weight 1.4859), DRG 843 (Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses with MCC, relative weight 1.9453) and 2 more, in MDC 17 (Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It was added in FY2019, effective October 1, 2018.

Coding notes

Applicable toConditions and synonyms classified to this code
  • Dysplasminogenemia
  • Hypoplasminogenemia
  • Type 1 plasminogen deficiency
  • Type 2 plasminogen deficiency
Use additional codeAdd a secondary code to fully describe the condition
  • code for associated findings, such as:
  • hydrocephalus (G91.4)
  • otitis media (H67.-)
  • respiratory disorder related to plasminogen deficiency (J99)
Code alsoTwo codes may be needed; sequencing depends on circumstances
  • , if applicable, ligneous conjunctivitis (H10.51-)

Notes that apply from higher levels

Instructions written at a parent level also apply to E88.02.

› From E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
Excludes1
  • monoclonal gammopathy (of undetermined significance) (D47.2)
  • polyclonal hypergammaglobulinemia (D89.0)
  • Waldenström macroglobulinemia (C88.00)
Excludes2
  • disorder of lipoprotein metabolism (E78.-)
› From E88 Other and unspecified metabolic disorders
Excludes1
  • histiocytosis X (chronic) (C96.6)
Use additional code
  • codes for associated conditions

Broader instructions also apply from E70-E88 Metabolic disorders and Chapter 4: Endocrine, nutritional and metabolic diseases.

Alphabetic index entries

3 entries

Terms in the official ICD-10-CM index that lead to E88.02.

Codes whose notes reference E88.02

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2019 (effective 10/1/2018): Added
  • No changes since FY2019.

Common questions about E88.02

Is E88.02 billable?

Yes. E88.02 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can E88.02 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict E88.02 as a principal diagnosis.

Is E88.02 a CC or MCC?

E88.02 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.

What DRG does E88.02 group to?

E88.02 is used in the MS-DRG v44.0 logic for MS-DRG 826 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with MCC), MS-DRG 827 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with CC), MS-DRG 828 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures without CC/MCC), MS-DRG 829 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures with CC/MCC), MS-DRG 830 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures without CC/MCC), MS-DRG 843 (Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses with MCC) and 2 more. Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.