E88.0Disorders of plasma-protein metabolism, not elsewhere classified

E88.0 is the ICD-10-CM diagnosis code for disorders of plasma-protein metabolism, not elsewhere classified. It belongs to category E88 (other and unspecified metabolic disorders), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is a header code, so it can't be reported by itself; one of its 3 subcodes must be used instead.

Within E88 (other and unspecified metabolic disorders), E88.0 is specifically for disorders of plasma-protein metabolism, not elsewhere classified. Related codes cover lipodystrophy, not elsewhere classified (E88.1), Lipomatosis, not elsewhere classified (E88.2), tumor lysis syndrome (E88.3), mitochondrial metabolism disorders (E88.4), other specified metabolic disorders (E88.8), metabolic disorder, unspecified (E88.9) and wasting disease (syndrome) due to underlying condition (E88.A).

To report this condition, pick the subcode that matches the documentation: E88.01 (deficiency), E88.02 (deficiency) and E88.09 (classified).

Don't report E88.0 together with the conditions in its Excludes1 note: monoclonal gammopathy (of undetermined significance) (D47.2), polyclonal hypergammaglobulinemia (D89.0) and Waldenström macroglobulinemia (C88.00).

The conditions in its Excludes2 note aren't part of E88.0, but may be coded alongside it if the patient has both: disorder of lipoprotein metabolism (E78.-).

Use an additional code for: codes for associated conditions.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.