ICD-10-CM 2027
ICD-10 code for deficiency anemia
From the official ICD-10-CM alphabetic index entry “Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency”. Page updated September 29, 2026.
About coding deficiency anemia
The ICD-10-CM code for deficiency anemia is D53.9 (Nutritional anemia, unspecified). The official index lists 45 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on D53.9.
Within D53, choose D53.9 (Nutritional anemia, unspecified) only when documentation doesn't support a more specific option: protein deficiency anemia (D53.0), other megaloblastic anemias, not elsewhere classified (D53.1), Scorbutic anemia (D53.2) and other specified nutritional anemias (D53.8).
Don't report D53.9 together with the conditions in its Excludes1 note: anemia NOS (D64.9).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
More specific deficiency anemia codes (official index)
- 2, 3 diphosphoglycurate mutase D55.29 — Anemia due to other disorders of glycolytic enzymes
- 2, 3 PG D55.29 — Anemia due to other disorders of glycolytic enzymes
- 6 phosphogluconate dehydrogenase D55.1 — Anemia due to other disorders of glutathione metabolism
- 6-PGD D55.1 — Anemia due to other disorders of glutathione metabolism
- amino-acid D53.0 — Protein deficiency anemia
- combined B12 and folate D53.1 — Other megaloblastic anemias, not elsewhere classified
- enzyme D55.9 — Anemia due to enzyme disorder, unspecified
- drug-induced (hemolytic) D59.2 — Drug-induced nonautoimmune hemolytic anemia
- glucose-6-phosphate dehydrogenase (G6PD) D55.0 — Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
- glycolytic D55.29 — Anemia due to other disorders of glycolytic enzymes
- nucleotide metabolism D55.3 — Anemia due to disorders of nucleotide metabolism
- related to hexose monophosphate (HMP) shunt pathway NEC D55.1 — Anemia due to other disorders of glutathione metabolism
- specified type NEC D55.8 — Other anemias due to enzyme disorders
- erythrocytic glutathione D55.1 — Anemia due to other disorders of glutathione metabolism
- folate D52.9 — Folate deficiency anemia, unspecified
- dietary D52.0 — Dietary folate deficiency anemia
- drug-induced D52.1 — Drug-induced folate deficiency anemia
- folic acid D52.9 — Folate deficiency anemia, unspecified
- dietary D52.0 — Dietary folate deficiency anemia
- drug-induced D52.1 — Drug-induced folate deficiency anemia
- G SH D55.1 — Anemia due to other disorders of glutathione metabolism
- GGS-R D55.1 — Anemia due to other disorders of glutathione metabolism
- glucose-6-phosphate dehydrogenase D55.0 — Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
- glutathione reductase D55.1 — Anemia due to other disorders of glutathione metabolism
- glyceraldehyde phosphate dehydrogenase D55.29 — Anemia due to other disorders of glycolytic enzymes
- G6PD D55.0 — Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
- hexokinase D55.29 — Anemia due to other disorders of glycolytic enzymes
- iron D50.9 — Iron deficiency anemia, unspecified
- secondary to blood loss (chronic) D50.0 — Iron deficiency anemia secondary to blood loss (chronic)
- nutritional D53.9 — Nutritional anemia, unspecified
- with
- poor iron absorption D50.8 — Other iron deficiency anemias
- specified deficiency NEC D53.8 — Other specified nutritional anemias
- phosphofructo-aldolase D55.29 — Anemia due to other disorders of glycolytic enzymes
- phosphoglycerate kinase D55.29 — Anemia due to other disorders of glycolytic enzymes
- PK D55.21 — Anemia due to pyruvate kinase deficiency
- protein D53.0 — Protein deficiency anemia
- pyruvate kinase D55.21 — Anemia due to pyruvate kinase deficiency
- transcobalamin II D51.2 — Transcobalamin II deficiency
- triose-phosphate isomerase D55.29 — Anemia due to other disorders of glycolytic enzymes
- vitamin B12 NOS D51.9 — Vitamin B12 deficiency anemia, unspecified
- dietary D51.3 — Other dietary vitamin B12 deficiency anemia
- due to
- intrinsic factor deficiency D51.0 — Vitamin B12 deficiency anemia due to intrinsic factor deficiency
- selective vitamin B12 malabsorption with proteinuria D51.1 — Vitamin B12 deficiency anemia due to selective vitamin B12 malabsorption with proteinuria
- pernicious D51.0 — Vitamin B12 deficiency anemia due to intrinsic factor deficiency
- specified type NEC D51.8 — Other vitamin B12 deficiency anemias
Don't confuse with (Excludes1 for D53.9)
- anemia NOS (D64.9)
Common questions about deficiency anemia ICD-10 codes
What is the ICD-10 code for deficiency anemia?
- D53.9 — Nutritional anemia, unspecified. More specific codes apply when the documentation supports them: D55.29, D55.29, D55.1, D55.1 and others below.
What is the ICD-10 code for 6 phosphogluconate dehydrogenase deficiency anemia?
- D55.1 — Anemia due to other disorders of glutathione metabolism.
What is the ICD-10 code for 6-pgd deficiency anemia?
- D55.1 — Anemia due to other disorders of glutathione metabolism.
What is the ICD-10 code for amino-acid deficiency anemia?
- D53.0 — Protein deficiency anemia.
What is the ICD-10 code for combined b12 and folate deficiency anemia?
- D53.1 — Other megaloblastic anemias, not elsewhere classified.
What is the ICD-10 code for enzyme deficiency anemia?
- D55.9 — Anemia due to enzyme disorder, unspecified.
What is the ICD-10 code for erythrocytic glutathione deficiency anemia?
- D55.1 — Anemia due to other disorders of glutathione metabolism.
Is D53.9 billable?
- Yes. D53.9 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D53.9 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D53.9 as a principal diagnosis.
Is D53.9 a CC or MCC?
- No. D53.9 is neither a CC nor an MCC under MS-DRG v44.0.