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ICD-10-CM 2027 diagnosis code

D48.3Neoplasm of uncertain behavior of retroperitoneum

✓ Billable / specific

D48.3 is a valid, billable ICD-10-CM code for neoplasm of uncertain behavior of retroperitoneum. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About D48.3

D48.3 is the ICD-10-CM diagnosis code for neoplasm of uncertain behavior of retroperitoneum. It belongs to category D48 (neoplasm of uncertain behavior of other and unspecified sites), block D37-D48 (neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes) and chapter 2 (neoplasms). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within D48 (neoplasm of uncertain behavior of other and unspecified sites), D48.3 is specifically for neoplasm of uncertain behavior of retroperitoneum. Related codes cover behavior of bone and articular cartilage (D48.0), behavior of connective and other soft tissue (D48.1), behavior of peripheral nerves and autonomic nervous system (D48.2), behavior of peritoneum (D48.4), behavior of skin (D48.5), behavior of breast (D48.6), behavior of other specified sites (D48.7) and behavior, unspecified (D48.9).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 374 (Digestive Malignancy with MCC, relative weight 2.1109), DRG 375 (Digestive Malignancy with CC, relative weight 1.1838) and DRG 376 (Digestive Malignancy without CC/MCC, relative weight 0.8929), in MDC 06 (Diseases and Disorders of the Digestive System), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 235.4 (neoplasm of uncertain behavior of retroperitoneum and peritoneum).

Notes that apply from higher levels

Instructions written at a parent level also apply to D48.3.

› From D48 Neoplasm of uncertain behavior of other and unspecified sites
Excludes1
  • neurofibromatosis (nonmalignant) (Q85.0-)

Broader instructions also apply from D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes and Chapter 2: Neoplasms.

Alphabetic index entries

1 entries

Terms in the official ICD-10-CM index that lead to D48.3.

Table of Drugs & Neoplasms entries

Codes whose notes reference D48.3

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

ICD-9-CM equivalent

Converter →
  • 235.4Neoplasm of uncertain behavior of retroperitoneum and peritoneumapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about D48.3

Is D48.3 billable?

Yes. D48.3 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can D48.3 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict D48.3 as a principal diagnosis.

Is D48.3 a CC or MCC?

No. D48.3 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does D48.3 group to?

D48.3 is used in the MS-DRG v44.0 logic for MS-DRG 374 (Digestive Malignancy with MCC), MS-DRG 375 (Digestive Malignancy with CC) and MS-DRG 376 (Digestive Malignancy without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for D48.3?

The CMS General Equivalence Mappings map D48.3 to ICD-9-CM 235.4.