Skip to content
Dx

ICD-10-CM 2027 diagnosis code

D48.2Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system

✓ Billable / specific

D48.2 is a valid, billable ICD-10-CM code for neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.Short description: Neoplm of uncrt behav of prph nerves and autonm nervous sys

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About D48.2

D48.2 is the ICD-10-CM diagnosis code for neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system. It belongs to category D48 (neoplasm of uncertain behavior of other and unspecified sites), block D37-D48 (neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes) and chapter 2 (neoplasms). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within D48 (neoplasm of uncertain behavior of other and unspecified sites), D48.2 is specifically for neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system. Related codes cover behavior of bone and articular cartilage (D48.0), behavior of connective and other soft tissue (D48.1), behavior of retroperitoneum (D48.3), behavior of peritoneum (D48.4), behavior of skin (D48.5), behavior of breast (D48.6), behavior of other specified sites (D48.7) and behavior, unspecified (D48.9).

Don't report D48.2 together with the conditions in its Excludes1 note: neoplasm of uncertain behavior of peripheral nerves of orbit (D48.7).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 564 (Other Musculoskeletal System and Connective Tissue Diagnoses with MCC, relative weight 1.4908), DRG 565 (Other Musculoskeletal System and Connective Tissue Diagnoses with CC, relative weight 0.9783) and DRG 566 (Other Musculoskeletal System and Connective Tissue Diagnoses without CC/MCC, relative weight 0.7378), in MDC 08 (Diseases and Disorders of the Musculoskeletal System and Connective Tissue), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 238.1 (neoplasm of uncertain behavior of connective and other soft tissue).

Coding notes

Excludes1Not coded here — never report together with this code
  • neoplasm of uncertain behavior of peripheral nerves of orbit (D48.7)

Notes that apply from higher levels

Instructions written at a parent level also apply to D48.2.

› From D48 Neoplasm of uncertain behavior of other and unspecified sites
Excludes1
  • neurofibromatosis (nonmalignant) (Q85.0-)

Broader instructions also apply from D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes and Chapter 2: Neoplasms.

Table of Drugs & Neoplasms entries

Codes whose notes reference D48.2

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

ICD-9-CM equivalent

Converter →
  • 238.1Neoplasm of uncertain behavior of connective and other soft tissueapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about D48.2

Is D48.2 billable?

Yes. D48.2 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can D48.2 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict D48.2 as a principal diagnosis.

Is D48.2 a CC or MCC?

No. D48.2 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does D48.2 group to?

D48.2 is used in the MS-DRG v44.0 logic for MS-DRG 564 (Other Musculoskeletal System and Connective Tissue Diagnoses with MCC), MS-DRG 565 (Other Musculoskeletal System and Connective Tissue Diagnoses with CC) and MS-DRG 566 (Other Musculoskeletal System and Connective Tissue Diagnoses without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for D48.2?

The CMS General Equivalence Mappings map D48.2 to ICD-9-CM 238.1.