ICD-10-CM 2027 diagnosis code

D48.6Neoplasm of uncertain behavior of breast

Not billable — use a more specific code

D48.6 is a header code, so it can't be reported by itself. Choose one of the 3 more specific codes beneath it.

Looking up by condition? See ICD-10 code for Cystosarcoma phyllodes.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About D48.6

D48.6 is the ICD-10-CM diagnosis code for neoplasm of uncertain behavior of breast. It belongs to category D48 (neoplasm of uncertain behavior of other and unspecified sites), block D37-D48 (neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes) and chapter 2 (neoplasms). It is a header code, so it can't be reported by itself; one of its 3 subcodes must be used instead.

Within D48 (neoplasm of uncertain behavior of other and unspecified sites), D48.6 is specifically for neoplasm of uncertain behavior of breast. Related codes cover behavior of bone and articular cartilage (D48.0), behavior of connective and other soft tissue (D48.1), behavior of peripheral nerves and autonomic nervous system (D48.2), behavior of retroperitoneum (D48.3), behavior of peritoneum (D48.4), behavior of skin (D48.5), behavior of other specified sites (D48.7) and behavior, unspecified (D48.9).

To report this condition, pick the subcode that matches the documentation: D48.60 (breast), D48.61 (breast) and D48.62 (breast).

Don't report D48.6 together with the conditions in its Excludes1 note: neoplasm of uncertain behavior of skin of breast (D48.5).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Specific codes under D48.6

Coding notes

Applicable toConditions and synonyms classified to this code

Neoplasm of uncertain behavior of connective tissue of breast
Cystosarcoma phyllodes

Excludes1Not coded here — never report together with this code

neoplasm of uncertain behavior of skin of breast (D48.5)

Notes that apply from higher levels

Instructions written at a parent level also apply to D48.6.

› From D48 Neoplasm of uncertain behavior of other and unspecified sites

Excludes1

neurofibromatosis (nonmalignant) (Q85.0-)

Broader instructions also apply from D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes and Chapter 2: Neoplasms.

Alphabetic index entries

2 entries

Terms in the official ICD-10-CM index that lead to D48.6.

Table of Drugs & Neoplasms entries

Neoplasm, neoplastic › areola — Uncertain Behavior
Neoplasm, neoplastic › breast (connective tissue) (glandular tissue) (soft parts) — Uncertain Behavior
Neoplasm, neoplastic › breast (connective tissue) (glandular tissue) (soft parts) › areola — Uncertain Behavior
Neoplasm, neoplastic › breast (connective tissue) (glandular tissue) (soft parts) › axillary tail — Uncertain Behavior
Neoplasm, neoplastic › breast (connective tissue) (glandular tissue) (soft parts) › central portion — Uncertain Behavior
Neoplasm, neoplastic › breast (connective tissue) (glandular tissue) (soft parts) › inner — Uncertain Behavior
Neoplasm, neoplastic › breast (connective tissue) (glandular tissue) (soft parts) › lower — Uncertain Behavior
Neoplasm, neoplastic › breast (connective tissue) (glandular tissue) (soft parts) › lower-inner quadrant — Uncertain Behavior
Neoplasm, neoplastic › breast (connective tissue) (glandular tissue) (soft parts) › lower-outer quadrant — Uncertain Behavior
Neoplasm, neoplastic › breast (connective tissue) (glandular tissue) (soft parts) › midline — Uncertain Behavior
Neoplasm, neoplastic › breast (connective tissue) (glandular tissue) (soft parts) › nipple — Uncertain Behavior
Neoplasm, neoplastic › breast (connective tissue) (glandular tissue) (soft parts) › outer — Uncertain Behavior
Neoplasm, neoplastic › breast (connective tissue) (glandular tissue) (soft parts) › tail (axillary) — Uncertain Behavior
Neoplasm, neoplastic › breast (connective tissue) (glandular tissue) (soft parts) › upper — Uncertain Behavior
Neoplasm, neoplastic › breast (connective tissue) (glandular tissue) (soft parts) › upper-inner quadrant — Uncertain Behavior
Neoplasm, neoplastic › breast (connective tissue) (glandular tissue) (soft parts) › upper-outer quadrant — Uncertain Behavior

Codes whose notes reference D48.6

D48.1Excludes1

Code history

2016
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2018
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2021
2022
2023
2024
2025
2026
2027

FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
No changes since FY2016.

Common questions about D48.6

Is D48.6 billable?: No. D48.6 is a header code. Report one of its more specific subcodes instead.