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ICD-10-CM 2027 diagnosis code

D81.2Severe combined immunodeficiency [SCID] with low or normal B-cell numbers

✓ Billable / specificCC — complication/comorbidity

D81.2 is a valid, billable ICD-10-CM code for severe combined immunodeficiency [scid] with low or normal b-cell numbers. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.Short description: Severe combined immunodef w low or normal B-cell numbers

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About D81.2

D81.2 is the ICD-10-CM diagnosis code for severe combined immunodeficiency [SCID] with low or normal B-cell numbers. It belongs to category D81 (combined immunodeficiencies), block D80-D89 (certain disorders involving the immune mechanism) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within D81 (combined immunodeficiencies), D81.2 is specifically for severe combined immunodeficiency [SCID] with low or normal B-cell numbers. Related codes cover severe combined immunodeficiency [SCID] with reticular dysgenesis (D81.0), severe combined immunodeficiency [SCID] with low T- and B-cell numbers (D81.1), adenosine deaminase [ADA] deficiency (D81.3), Nezelof's syndrome (D81.4), purine nucleoside phosphorylase [PNP] deficiency (D81.5), major histocompatibility complex class I deficiency (D81.6), major histocompatibility complex class II deficiency (D81.7), other combined immunodeficiencies (D81.8) and 1 more.

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 808 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC, relative weight 2.1705), DRG 809 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC, relative weight 1.2262) and DRG 810 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC, relative weight 1.075), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 279.2 (combined immunity deficiency).

Notes that apply from higher levels

Instructions written at a parent level also apply to D81.2.

› From D81 Combined immunodeficiencies
Excludes1
  • autosomal recessive agammaglobulinemia (Swiss type) (D80.0)

Broader instructions also apply from D80-D89 Certain disorders involving the immune mechanism and Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism.

Alphabetic index entries

1 entries

Terms in the official ICD-10-CM index that lead to D81.2.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

ICD-9-CM equivalent

Converter →
  • 279.2Combined immunity deficiencyapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about D81.2

Is D81.2 billable?

Yes. D81.2 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can D81.2 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict D81.2 as a principal diagnosis.

Is D81.2 a CC or MCC?

D81.2 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.

What DRG does D81.2 group to?

D81.2 is used in the MS-DRG v44.0 logic for MS-DRG 808 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC), MS-DRG 809 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC) and MS-DRG 810 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for D81.2?

The CMS General Equivalence Mappings map D81.2 to ICD-9-CM 279.2.